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1,3,6-Tri-O-galloyl-beta-D-glucose

🥰Excellent
Catalog No. TN1166Cas No. 18483-17-5
Alias 1,3,6-Tri-O-galloyl-β-D-glucose, 1,3,6-Tri-O-galloylglucose

1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound found in Black Walnut Kernels, exhibiting anti-inflammatory activity.

1,3,6-Tri-O-galloyl-beta-D-glucose

1,3,6-Tri-O-galloyl-beta-D-glucose

🥰Excellent
Purity: 99.47%
Catalog No. TN1166Alias 1,3,6-Tri-O-galloyl-β-D-glucose, 1,3,6-Tri-O-galloylglucoseCas No. 18483-17-5
1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound found in Black Walnut Kernels, exhibiting anti-inflammatory activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$118In StockIn Stock
5 mg$291In StockIn Stock
10 mg$432In StockIn Stock
25 mg$716In StockIn Stock
50 mg$987In StockIn Stock
1 mL x 10 mM (in DMSO)$396In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.47%
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Product Introduction

Bioactivity
Description
1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound found in Black Walnut Kernels, exhibiting anti-inflammatory activity.
In vitro
The compounds were isolated by silica gel column chromatography, Sephadex LH-20 column chromatography and ODS column chromatography.Their structures were elucidated by spectral analyses and physicochemical properties. The anti-inflammatory activities of selected isolated compounds were evaluated as inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cell lines by Griess reaction. Eight compounds were obtained from n-butanol fraction oi Mangifera indica L. seed kernel, whose structures were elucidated as 4-O-ethylgallic acid (1), gallic acid (2), citric acid(3), 1,2,3,4,6-penta-O-galloylglucose(4),1,3,6-Tri-O-galloylglucose(5), hyperoside(6), quercetin-3-O-rhamnopyranoside(7), and mangiferin(8). Compounds 1, 2 and 4-8 exhibited potent inhibitory effect on NO production in LPS-induced macrophages, especially compounds 6 and 8 showed the best inhibitory activity with IC50 values of 16.5 and 19.5 μmol·L-1, respectively.
Synonyms1,3,6-Tri-O-galloyl-β-D-glucose, 1,3,6-Tri-O-galloylglucose
Chemical Properties
Molecular Weight636.47
FormulaC27H24O18
Cas No.18483-17-5
SmilesO[C@@H]1[C@@H](COC(=O)c2cc(O)c(O)c(O)c2)O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](O)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1
Relative Density.1.98 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 1 mg/mL (1.57 mM), Sonication and heating are recommended.
DMSO: 100 mg/mL (157.12 mM), Sonication and heating are recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.18 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.5712 mL7.8558 mL15.7117 mL78.5583 mL
DMSO
1mg5mg10mg50mg
5 mM0.3142 mL1.5712 mL3.1423 mL15.7117 mL
10 mM0.1571 mL0.7856 mL1.5712 mL7.8558 mL
20 mM0.0786 mL0.3928 mL0.7856 mL3.9279 mL
50 mM0.0314 mL0.1571 mL0.3142 mL1.5712 mL
100 mM0.0157 mL0.0786 mL0.1571 mL0.7856 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

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