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MB05032

Name: MB05032
Brand: TargetMol
SKU: T16020
Rating: 4.5 (1 reviews)

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Catalog No. T16020Cas No. 261365-11-1

Alias MB-05032, MB 05032

MB05032 is a potent fructose-,-bisphosphatase inhibitor that inhibits gluconeogenesis and reduces d-lactate-triggered ETosis.

MB05032

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Purity: 99.66%

Catalog No. T16020Alias MB-05032, MB 05032Cas No. 261365-11-1

MB05032 is a potent fructose-,-bisphosphatase inhibitor that inhibits gluconeogenesis and reduces d-lactate-triggered ETosis.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$112	5 days	5 days
25 mg	$613	6-8 weeks	6-8 weeks
50 mg	$797	6-8 weeks	6-8 weeks
100 mg	$1,390	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$217	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly

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Purity:99.66%

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COA

Product Introduction

Bioactivity

Description	MB05032 is a potent fructose-,-bisphosphatase inhibitor that inhibits gluconeogenesis and reduces d-lactate-triggered ETosis.
Targets&IC50	FBPase (human Liver):16 nM
In vivo	METHODS: To investigate the therapeutic effect of MB05032 on gluconeogenesis in type 2 diabetes, MB05032 was orally administered at different doses (3-300 mg/kg; once) to young and aged ZDF rats. RESULTS: MB05032 resulted in a dose-dependent decrease in blood glucose levels.
Synonyms	MB-05032, MB 05032

Chemical Properties

Molecular Weight	302.29
Formula	C₁₁H₁₅N₂O₄PS
Cas No.	261365-11-1
Smiles	O=P(O)(O)C=1OC(=CC1)C=2N=C(SC2CC(C)C)N
Relative Density.	1.47 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (132.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.62 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3081 mL	16.5404 mL	33.0808 mL	165.4041 mL
5 mM	0.6616 mL	3.3081 mL	6.6162 mL	33.0808 mL
10 mM	0.3308 mL	1.6540 mL	3.3081 mL	16.5404 mL
20 mM	0.1654 mL	0.8270 mL	1.6540 mL	8.2702 mL
50 mM	0.0662 mL	0.3308 mL	0.6616 mL	3.3081 mL
100 mM	0.0331 mL	0.1654 mL	0.3308 mL	1.6540 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc