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MG-T-19
🥰Excellent
Catalog No. T201721Cas No. 328540-44-9
Alias MGT-19, MG T19
MG-T-19, a TIM-3 inhibitor (KD=0.26 μM), significantly inhibited the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs, which reactivated the tumor-attacking ability of T cells.
MG-T-19
🥰Excellent
Purity: 99.14%
Catalog No. T201721Alias MGT-19, MG T19Cas No. 328540-44-9
MG-T-19, a TIM-3 inhibitor (KD=0.26 μM), significantly inhibited the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs, which reactivated the tumor-attacking ability of T cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | - | In Stock | |
| 10 mg | $692 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,970 | - | In Stock | |
| 200 mg | $2,690 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.14%
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Product Introduction
Bioactivity
Chemical Properties
| Description | MG-T-19, a TIM-3 inhibitor (KD=0.26 μM), significantly inhibited the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs, which reactivated the tumor-attacking ability of T cells. |
| In vitro | MG-T-19 is a mannose-derived compound with antimicrobial activity. In vitro, MG-T-19 (2-16 μg/mL) effectively inhibits the growth of various Pseudomonas aeruginosa strains, including drug-resistant clinical isolates. MG-T-19 blocks bacterial adhesion to host cells and prevents biofilm formation across different human cell models[1]. |
| In vivo | In a murine lung infection model, MG-T-19 (10 mg/kg, intranasal administration) significantly reduces bacterial burden in lung tissue, alleviates histopathological damage, and improves survival. MG-T-19 also enhances the efficacy of antibiotics like ceftazidime, showing synergistic antimicrobial effects[1]. |
| Synonyms | MGT-19, MG T19 |
| Molecular Weight | 596.6 |
| Formula | C18H8Br2ClF3N4O2S |
| Cas No. | 328540-44-9 |
| Smiles | O=C(NC1=CC(Cl)=CC=C1O)C2=NN3C(N=C(C=C3C(F)(F)F)C=4SC=C(Br)C4)=C2Br |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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