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Lenalidomide-Br

🥰Excellent
Catalog No. T18064Cas No. 2093387-36-9

Lenalidomide-Br (Compound 41), a derivative of Lenalidomide, acts as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound can be conjugated to a protein ligand via a linker to create PROTACs, such as the PROTAC STAT3 degrader SD-36.

Lenalidomide-Br

Lenalidomide-Br

🥰Excellent
Purity: 98.37%
Catalog No. T18064Cas No. 2093387-36-9
Lenalidomide-Br (Compound 41), a derivative of Lenalidomide, acts as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound can be conjugated to a protein ligand via a linker to create PROTACs, such as the PROTAC STAT3 degrader SD-36.
Pack SizePriceAvailabilityQuantity
100 mg$29In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:98.37%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Lenalidomide-Br (Compound 41), a derivative of Lenalidomide, acts as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound can be conjugated to a protein ligand via a linker to create PROTACs, such as the PROTAC STAT3 degrader SD-36.
In vitro
Lenalidomide-Br can be conjugated to a protein ligand via a linker, forming PROTACs that induce the ubiquitination-mediated degradation of oncogenic proteins.
In vivo
Lenalidomide-Br can form a PROTAC by coupling with a protein's ligand. PROTAC acts as an inducer of ubiquitin-mediated degradation of oncogenic proteins [1][2].
Chemical Properties
Molecular Weight323.14
FormulaC13H11BrN2O3
Cas No.2093387-36-9
SmilesO=C1N(CC=2C1=CC=CC2Br)C3C(=O)NC(=O)CC3
Relative Density.1.688 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (92.84 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.09 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0946 mL15.4732 mL30.9463 mL154.7317 mL
5 mM0.6189 mL3.0946 mL6.1893 mL30.9463 mL
10 mM0.3095 mL1.5473 mL3.0946 mL15.4732 mL
20 mM0.1547 mL0.7737 mL1.5473 mL7.7366 mL
50 mM0.0619 mL0.3095 mL0.6189 mL3.0946 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ubiquitinrecruitmentproteinPROTACligaseLigands for E3 LigaseLigandforE3LigaseLigand for E3 LigaseLenalidomide-BrLenalidomideBrLenalidomide BrInhibitorinhibitE3 ligase-recruiting MoietycereblonCereblonanalog
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