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N,N-Dimethylsphingosine

Name: N,N-Dimethylsphingosine
Brand: TargetMol
SKU: T23045
Price: 253 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23045Cas No. 119567-63-4

Alias N,N-Dimethylsphingosine (d18:1), DMS, D-erythro-N,N-dimethylsphingosin

N,N-Dimethylsphingosine, an endogenous metabolite, is a potent competitive sphingosine kinase (SphK) inhibitor that selectively inhibits sphingosine phosphorylation without affecting its N-acylation.DMS is elevated in models of neuropathic pain, and may mediate mechanical nociception by increasing the release of IL-1β and MCP-1.

N,N-Dimethylsphingosine

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Catalog No. T23045Alias N,N-Dimethylsphingosine (d18:1), DMS, D-erythro-N,N-dimethylsphingosinCas No. 119567-63-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$253	-	In Stock
10 mg	$475	-	In Stock
25 mg	$1,080	-	In Stock
50 mg	$1,970	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	N,N-Dimethylsphingosine, an endogenous metabolite, is a potent competitive sphingosine kinase (SphK) inhibitor that selectively inhibits sphingosine phosphorylation without affecting its N-acylation.DMS is elevated in models of neuropathic pain, and may mediate mechanical nociception by increasing the release of IL-1β and MCP-1.
In vitro	Methods: RAW264.7 cells were treated with N,N-Dimethylsphingosine (0-5μM, 24 hours), and cell viability was determined by MTT assay. Results: N,N-Dimethylsphingosine can inhibit the growth of RAW264.7 cells with an IC50 value of 2.3μM. [1]
Synonyms	N,N-Dimethylsphingosine (d18:1), DMS, D-erythro-N,N-dimethylsphingosin

Chemical Properties

Molecular Weight	327.55
Formula	C₂₀H₄₁NO₂
Cas No.	119567-63-4
Smiles	CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)N(C)C
Relative Density.	0.921 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 20 mg/mL (61.06 mM), Sonication is recommended.

DMSO: 5 mg/mL (15.26 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.0530 mL	15.2648 mL	30.5297 mL	152.6485 mL
5 mM	0.6106 mL	3.0530 mL	6.1059 mL	30.5297 mL
10 mM	0.3053 mL	1.5265 mL	3.0530 mL	15.2648 mL

Ethanol

	1mg	5mg	10mg	50mg
20 mM	0.1526 mL	0.7632 mL	1.5265 mL	7.6324 mL
50 mM	0.0611 mL	0.3053 mL	0.6106 mL	3.0530 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc