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PLK1/BRD4-IN-3

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Catalog No. T87990Cas No. 2251709-91-6

Compound 21, also known as PLK1/BRD4-IN-3, acts as a selective dual inhibitor targeting both bromodomain 4 (BRD4) and polo-like kinase 1 (PLK1). It effectively inhibits BRD4-BD1, PLK1, and BRDT-BD1, exhibiting IC50 values of 0.059, 0.127, and 0.245 μM, respectively.

PLK1/BRD4-IN-3

PLK1/BRD4-IN-3

😃Good
Catalog No. T87990Cas No. 2251709-91-6
Compound 21, also known as PLK1/BRD4-IN-3, acts as a selective dual inhibitor targeting both bromodomain 4 (BRD4) and polo-like kinase 1 (PLK1). It effectively inhibits BRD4-BD1, PLK1, and BRDT-BD1, exhibiting IC50 values of 0.059, 0.127, and 0.245 μM, respectively.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,97010-14 weeks10-14 weeks
50 mg$2,58010-14 weeks10-14 weeks
100 mg$3,40010-14 weeks10-14 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Compound 21, also known as PLK1/BRD4-IN-3, acts as a selective dual inhibitor targeting both bromodomain 4 (BRD4) and polo-like kinase 1 (PLK1). It effectively inhibits BRD4-BD1, PLK1, and BRDT-BD1, exhibiting IC50 values of 0.059, 0.127, and 0.245 μM, respectively.
Targets&IC50
BRD4 BD1:0.059 μM, PLK1:0.127 μM, BRDT BD1:0.245 μM
Chemical Properties
Molecular Weight561.72
FormulaC31H43N7O3
Cas No.2251709-91-6
SmilesC[C@@H]1N(C=2C(=CN=C(NC3=C(OC4CCCC4)C=C(C(NC5CCN(C)CC5)=O)C=C3)N2)N(C)C1=O)C6CCCC6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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