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PDMP hydrochloride
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Catalog No. T36015Cas No. 73257-80-4
Alias PDMP (hydrochloride)
PDMP hydrochloride is a ceramide analog originally developed as an inhibitor of glucosylceramide synthase that contains four stereoisomers due to two adjacent chiral centers, and while total PDMP hydrochloride inhibits glucosylceramide synthase by approximately 90% at 0.8 μM in MDCK cell homogenates, the inhibitory activity resides in the D-threo (1R,2R) enantiomer, which also blocks β-1,4-galactosyltransferase 6, prevents lactosylceramide-driven neuroinflammation in experimental autoimmune encephalomyelitis, additionally, PDMP hydrochloride enhances curcumin-induced antiproliferative and pro-apoptotic effects in melanoma cells.
PDMP hydrochloride
😃Good
Catalog No. T36015Alias PDMP (hydrochloride)Cas No. 73257-80-4
PDMP hydrochloride is a ceramide analog originally developed as an inhibitor of glucosylceramide synthase that contains four stereoisomers due to two adjacent chiral centers, and while total PDMP hydrochloride inhibits glucosylceramide synthase by approximately 90% at 0.8 μM in MDCK cell homogenates, the inhibitory activity resides in the D-threo (1R,2R) enantiomer, which also blocks β-1,4-galactosyltransferase 6, prevents lactosylceramide-driven neuroinflammation in experimental autoimmune encephalomyelitis, additionally, PDMP hydrochloride enhances curcumin-induced antiproliferative and pro-apoptotic effects in melanoma cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $198 | 35 days | 35 days | |
| 25 mg | $478 | 35 days | 35 days | |
| 50 mg | $885 | 35 days | 35 days | |
| 100 mg | $1,680 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PDMP hydrochloride is a ceramide analog originally developed as an inhibitor of glucosylceramide synthase that contains four stereoisomers due to two adjacent chiral centers, and while total PDMP hydrochloride inhibits glucosylceramide synthase by approximately 90% at 0.8 μM in MDCK cell homogenates, the inhibitory activity resides in the D-threo (1R,2R) enantiomer, which also blocks β-1,4-galactosyltransferase 6, prevents lactosylceramide-driven neuroinflammation in experimental autoimmune encephalomyelitis, additionally, PDMP hydrochloride enhances curcumin-induced antiproliferative and pro-apoptotic effects in melanoma cells. |
| In vitro | In experimental assays utilizing human Acute Myeloid Leukemia (AML) cells, PDMP hydrochloride was applied at concentrations ranging from 10 to 25 μM in combination with the BCL-2 inhibitor ABT-737. This treatment regimen effectively sensitized the cells to ABT-737-induced cytotoxicity, resulting in enhanced mitochondrial apoptosis [1]. |
| Synonyms | PDMP (hydrochloride) |
| Molecular Weight | 427.03 |
| Formula | C23H39ClN2O3 |
| Cas No. | 73257-80-4 |
| Smiles | Cl.O=C(NC(CN1CCOCC1)C(O)C=2C=CC=CC2)CCCCCCCCC |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMF: 25 mg/mL (58.54 mM), Sonication is recommended. Ethanol:PBS(pH 7.2)(1:5): 0.05 mg/mL (0.12 mM), Sonication is recommended. DMSO: 24 mg/mL (56.2 mM), Sonication is recommended. Ethanol: 50 mg/mL (117.09 mM), Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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