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Faropenem daloxate

Name: Faropenem daloxate
Brand: TargetMol
SKU: T11265
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11265Cas No. 141702-36-5

Alias Faropenem medoxil

Faropenem daloxate (Faropenem medoxil) is useful for penem and antibiotics. Faropenem medoxomil has excellent in vitro activity against Streptococcus pneumoniae, Haemophilus influenzae and other key pathogens implicated in acute bacterial rhinosinusitis.Faropenem daloxate is the first oral penem in a new class of beta-lactam antibiotics.

Faropenem daloxate

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Catalog No. T11265Alias Faropenem medoxilCas No. 141702-36-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$46	In Stock	In Stock
5 mg	$109	In Stock	In Stock
10 mg	$169	-	In Stock
50 mg	$328	-	In Stock
1 mL x 10 mM (in DMSO)	$169	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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COA

Product Introduction

Faropenem daloxate AI Summary

Faropenem daloxate exhibits antibacterial activity against beta-lactamase-producing Bacillus anthracis strains with varying minimum inhibitory concentrations (MIC). It shows efficacy in Bacillus anthracis-infected BALB/c mouse models with different dosages and intervals post-infection, and demonstrates plasma protein binding in mouse and human models, along with key pharmacokinetic parameters such as clearance, half-life, and peak plasma concentration. Additionally, it displays antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentration after 48 hours, showing respective inhibitions of 3.56% and -0.1%. The compound has a hit score of 0.000691 against the SARS-CoV-2 USA-WA1/2020 strain in HRCE cells and inhibits SARS-CoV-2 3CL-Pro protease by 4.389% at 20 µM. Furthermore, Faropenem daloxate inhibits human HDAC6, with 31.1% inhibition using a commercial peptide substrate and -7.21% using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Faropenem daloxate (Faropenem medoxil) is useful for penem and antibiotics. Faropenem medoxomil has excellent in vitro activity against Streptococcus pneumoniae, Haemophilus influenzae and other key pathogens implicated in acute bacterial rhinosinusitis.Faropenem daloxate is the first oral penem in a new class of beta-lactam antibiotics.
Synonyms	Faropenem medoxil

Chemical Properties

Molecular Weight	397.4
Formula	C₁₇H₁₉NO₈S
Cas No.	141702-36-5
Smiles	[H][C@]12SC([C@H]3CCCO3)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(=O)OCc1oc(=O)oc1C
Relative Density.	1.55 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: ≥ 100 mg/mL (251.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5164 mL	12.5818 mL	25.1636 mL	125.8178 mL
5 mM	0.5033 mL	2.5164 mL	5.0327 mL	25.1636 mL
10 mM	0.2516 mL	1.2582 mL	2.5164 mL	12.5818 mL
20 mM	0.1258 mL	0.6291 mL	1.2582 mL	6.2909 mL
50 mM	0.0503 mL	0.2516 mL	0.5033 mL	2.5164 mL
100 mM	0.0252 mL	0.1258 mL	0.2516 mL	1.2582 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc