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Anti-MLKL Polyclonal Antibody
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Catalog No. TMAB-01149
Alias Mlkl, Mixed lineage kinase domain-like protein
Anti-MLKL Polyclonal Antibody is a Rabbit antibody targeting MLKL. Anti-MLKL Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-MLKL Polyclonal Antibody
Anti-MLKL Polyclonal Antibody
😃Good
Catalog No. TMAB-01149Alias Mlkl, Mixed lineage kinase domain-like protein
Anti-MLKL Polyclonal Antibody is a Rabbit antibody targeting MLKL. Anti-MLKL Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $221 | 7-10 days | |
| 100 μL | $374 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-MLKL Polyclonal Antibody is a Rabbit antibody targeting MLKL. Anti-MLKL Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Synonyms | Mlkl, Mixed lineage kinase domain-like protein |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat) |
| Verified Activity | Sample: Lane 1: Human HeLa cell lysates Lane 2: Human MCF-7 cell lysates Primary: Anti-MLKL (TMAB-01149) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54 kDa Observed band size: 50 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:400-800; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]. |
| Immunogen | Recombinant Protein: protein of mouse MLKL |
| Antigen Species | Mouse |
| Gene Name | MLKL |
| Gene ID | |
| Protein Name | Mixed lineage kinase domain-like protein |
| Uniprot ID | |
| Biology Area | Necroptosis,SARS Coronavirus,Other Kinases |
| Function | Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. |
| Molecular Weight | Theoretical: 54 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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