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PF-1355

Name: PF-1355
Brand: TargetMol
SKU: T3511
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3511Cas No. 1435467-38-1

Alias ZINC205721785, PF-06281355, PF 06281355

PF-1355 (PF 06281355) is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.

PF-1355

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Purity: 99.93%

Catalog No. T3511Alias ZINC205721785, PF-06281355, PF 06281355Cas No. 1435467-38-1

PF-1355 (PF 06281355) is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$43	In Stock
10 mg	$73	In Stock
25 mg	$118	In Stock
50 mg	$223	In Stock
100 mg	$322	In Stock
200 mg	$460	In Stock
500 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock

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Purity:99.93%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	PF-1355 (PF 06281355) is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.
In vitro	PF-1355 inhibits MPO activity in phorbol ester-stimulated human neutrophils as measured by taurine chlorination (EC50=1.47 μM) as well as lipopolysaccharide-treated human blood measuring residual MPO activity (EC50=2.03 μM) [1].
In vivo	Administering PF-1355 orally diminishes MPO activity in plasma, lessens vascular edema and neutrophil recruitment, and increases circulating cytokines levels. PF-1355 treatment entirely inhibits albuminuria and chronic renal dysfunction in a model of anti-glomerular basement membrane disease [1].
Synonyms	ZINC205721785, PF-06281355, PF 06281355

Chemical Properties

Molecular Weight	321.35
Formula	C₁₄H₁₅N₃O₄S
Cas No.	1435467-38-1
Smiles	COc1ccc(OC)c(c1)-c1cc(=O)[nH]c(=S)n1CC(N)=O
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (171.15 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1119 mL	15.5594 mL	31.1187 mL	155.5936 mL
5 mM	0.6224 mL	3.1119 mL	6.2237 mL	31.1187 mL
10 mM	0.3112 mL	1.5559 mL	3.1119 mL	15.5594 mL
20 mM	0.1556 mL	0.7780 mL	1.5559 mL	7.7797 mL
50 mM	0.0622 mL	0.3112 mL	0.6224 mL	3.1119 mL
100 mM	0.0311 mL	0.1556 mL	0.3112 mL	1.5559 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc