Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-κB, resulting in the suppression of secretion of uPA.

In highly invasive human breast cancer cells, Ganoderic acid H suppressed growth (cell proliferation and colony formation) and invasive behavior (adhesion, migration and invasion) of MDA-MB-231 cells[1]. Furthermore, the activity of Ganoderic acid H is linked to the hydroxylation in the positions 7 and 3 in its triterpene lanostane structure[1]. Ganoderic acid H could be a promising natural agent for the therapy of invasive breast cancers[1].