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MMP-3 Inhibitor acetate

Catalog No. T37048L

Synonyms: MMP-3 Inhibitor acetate(158841-76-0 Free base)

MMP-3 Inhibitor acetate is a cell-permeable and potent inhibitor of human MMP-3.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MMP-3 Inhibitor acetate Chemical Structure

MMP-3 Inhibitor acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 195.00
5 mg	Inquiry	$ 437.00
10 mg	Inquiry	$ 655.00
25 mg	Inquiry	$ 1,178.00
50 mg	Inquiry	$ 1,768.00
100 mg	Inquiry	$ 2,652.00
200 mg	Inquiry	$ 3,978.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	MMP-3 Inhibitor acetate is a cell-permeable and potent inhibitor of human MMP-3.
In vitro	MMP3 inhibitor 1 (Compound 27) inhibits MMP-1, MMP-2, MMP-9, and MMP-14 with IC50s of 14000, 529, 2420, and 20100 nM, respectively[1].
In vivo	MMP-3 Inhibitor is a cell-permeable p-methoxysulfonamido D-leucine containing hydroxamate compound that acts as a potent inhibitor of human MMP-3 (stromelysin; Ki = 23 nM) and murine macrophage metalloelastase (MME/MMP-12; IC50 = 13 nM). Binds to the MMP active site Zn2+ [2] [3].

Synonyms	MMP-3 Inhibitor acetate(158841-76-0 Free base)
Molecular Weight	746.83
Formula	C29H50N10O11S

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Gavin A Whitlock, et al. A novel series of highly selective inhibitors of MMP-3. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6750-3. 2. Ai Ing Lim, et al. Distinct role of matrix metalloproteinase-3 in kidney injury molecule-1 shedding by kidney proximal tubular epithelial cells. Int J Biochem Cell Biol. 2012 Jun;44(6):1040-50. 3. Ran Gao, et al. Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis. J Biol Chem. 2013 May 24;288(21):15046-56.

Related Products

Related compounds with same targets

Histatin 5 (TFA)(115966-68-2,free) Muscone PNU-248686A TMI-1 Apratastat MMP13-IN-3 isomer-CM 352 Astragaloside IV

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MMP-3 Inhibitor acetate Proteases/Proteasome MMP MMP 3 Inhibitor acetate MMP-3 Inhibitor Acetate MMP-3 Inhibitor acetate(158841-76-0 Free base) MMP3 Inhibitor acetate inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.