MMP-3 Inhibitor acetate

Name: MMP-3 Inhibitor acetate
Brand: TargetMol
SKU: T37048L
Rating: 4.5 (1 reviews)

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Catalog No. T37048L

Alias MMP-3 Inhibitor acetate(158841-76-0 Free base)

MMP-3 Inhibitor acetate is a cell-permeable and potent inhibitor of human MMP-3.

MMP-3 Inhibitor acetate

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Catalog No. T37048LAlias MMP-3 Inhibitor acetate(158841-76-0 Free base)

MMP-3 Inhibitor acetate is a cell-permeable and potent inhibitor of human MMP-3.

Pack Size	Price	Availability
1 mg	$195	Backorder
5 mg	$437	Backorder
10 mg	$655	Backorder
25 mg	$1,178	Backorder
50 mg	$1,768	Backorder
100 mg	$2,652	Backorder
200 mg	$3,978	Backorder

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Product Introduction

Bioactivity

Description	MMP-3 Inhibitor acetate is a cell-permeable and potent inhibitor of human MMP-3.
In vitro	MMP3 inhibitor 1 (Compound 27) inhibits MMP-1, MMP-2, MMP-9, and MMP-14 with IC50s of 14000, 529, 2420, and 20100 nM, respectively[1].
In vivo	MMP-3 Inhibitor is a cell-permeable p-methoxysulfonamido D-leucine containing hydroxamate compound that acts as a potent inhibitor of human MMP-3 (stromelysin; Ki = 23 nM) and murine macrophage metalloelastase (MME/MMP-12; IC50 = 13 nM). Binds to the MMP active site Zn2+ [2] [3].
Synonyms	MMP-3 Inhibitor acetate(158841-76-0 Free base)

Chemical Properties

Molecular Weight	746.83
Formula	C₂₉H₅₀N₁₀O₁₁S
Sequence	Arg-Cys-Gly-Val-Pro-Asn
Sequence Short	RCGVPN

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc