Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-06761281 (Compound 4a) is a potent, orally active, partial selective inhibitor of sodium-coupled citrate transporter (NaCT or SLC13A5). The IC50 values of HEK NaCT, HEK NaDC1, and HEK NaDC3 are 0.51, 13.2 and 14.1 μM, respectively [1].
Description | PF-06761281 (Compound 4a) is a potent, orally active, partial selective inhibitor of sodium-coupled citrate transporter (NaCT or SLC13A5). The IC50 values of HEK NaCT, HEK NaDC1, and HEK NaDC3 are 0.51, 13.2 and 14.1 μM, respectively [1]. |
In vitro | PF-06761281 (Compound 4a) effectively inhibits citrate uptake in rat, mouse, and human hepatocytes (Heps), demonstrating inhibition concentration 50 (IC50) values of 0.12, 0.21, and 0.74 μM, respectively [1]. |
Molecular Weight | 283.28 |
Formula | C13H17NO6 |
CAS No. | 1854061-19-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PF-06761281 1854061-19-0 inhibitor inhibit