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KSC-34

Catalog No. T39704 CAS 2226201-97-2

KSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1).KSC-34 is a selective inhibitor targeting the a-site of PDIA1.It inhibits PDIA1 reductase activity in a time-dependent manner and is used to study diseases caused by abnormalities in amyloid.CAS 번호128-63-63-5

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KSC-34, CAS 2226201-97-2

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	KSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1).KSC-34 is a selective inhibitor targeting the a-site of PDIA1.It inhibits PDIA1 reductase activity in a time-dependent manner and is used to study diseases caused by abnormalities in amyloid.CAS 번호128-63-63-5
Targets&IC50	PDIA1 (a domain):3.5 μM, PDIA1 (a' domain):104.5 μM
In vitro	KSC-34 displays time-dependent inhibition of PDIA1 reductase activity in vitro with a kinact/ KI of 9.66 × 103 M-1 s-1 and is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins[1].

Molecular Weight	429.95
Formula	C21H28ClN7O
CAS No.	2226201-97-2

Storage

store under nitrogen

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (186.07 mM), Sonication is recommended.

References and Literature

1. Cole KS,et al. Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor. Biochemistry. 2018 Apr 3;57(13):2035-2043.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KSC-34 2226201-97-2 Others KSC34 KSC 34 inhibitor inhibit

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