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KSC-34

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Catalog No. T39704Cas No. 2226201-97-2

KSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1).KSC-34 is a selective inhibitor targeting the a-site of PDIA1.It inhibits PDIA1 reductase activity in a time-dependent manner and is used to study diseases caused by abnormalities in amyloid.128-63-63-5

KSC-34

KSC-34

🥰Excellent
Purity: 98%
Catalog No. T39704Cas No. 2226201-97-2
KSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1).KSC-34 is a selective inhibitor targeting the a-site of PDIA1.It inhibits PDIA1 reductase activity in a time-dependent manner and is used to study diseases caused by abnormalities in amyloid.128-63-63-5
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$149-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98%
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Product Introduction

Bioactivity
Description
KSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1).KSC-34 is a selective inhibitor targeting the a-site of PDIA1.It inhibits PDIA1 reductase activity in a time-dependent manner and is used to study diseases caused by abnormalities in amyloid.128-63-63-5
Targets&IC50
PDIA1 (a domain):3.5 μM, PDIA1 (a domain):104.5 μM
In vitro
KSC-34 displays time-dependent inhibition of PDIA1 reductase activity in vitro with a kinact/ KI of 9.66 × 103 M-1 s-1 and is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins[1].
Chemical Properties
Molecular Weight429.95
FormulaC21H28ClN7O
Cas No.2226201-97-2
SmilesO=C(NCCNC1=NC(=NC(=N1)N(C)CCCCC=2C=CC=CC2)NCC#C)CCl
Storage & Solubility Information
Storagestore under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (186.07 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.68 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3259 mL11.6293 mL23.2585 mL116.2926 mL
5 mM0.4652 mL2.3259 mL4.6517 mL23.2585 mL
10 mM0.2326 mL1.1629 mL2.3259 mL11.6293 mL
20 mM0.1163 mL0.5815 mL1.1629 mL5.8146 mL
50 mM0.0465 mL0.2326 mL0.4652 mL2.3259 mL
100 mM0.0233 mL0.1163 mL0.2326 mL1.1629 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

protein disulfide isomerase (PDI)KSC-34KSC34KSC 34
Related Tags: buy KSC-34 | purchase KSC-34 | KSC-34 cost | order KSC-34 | KSC-34 chemical structure | KSC-34 in vitro | KSC-34 formula | KSC-34 molecular weight
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