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Anti-ZEB1/NIL2A Polyclonal Antibody 2

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Catalog No. TMAB-14286

Anti-ZEB1/NIL2A Polyclonal Antibody 2 is a Rabbit antibody targeting ZEB1/NIL2A. Anti-ZEB1/NIL2A Polyclonal Antibody 2 can be used in WB.

Anti-ZEB1/NIL2A Polyclonal Antibody 2

Anti-ZEB1/NIL2A Polyclonal Antibody 2

😃Good
Catalog No. TMAB-14286
Anti-ZEB1/NIL2A Polyclonal Antibody 2 is a Rabbit antibody targeting ZEB1/NIL2A. Anti-ZEB1/NIL2A Polyclonal Antibody 2 can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2237-10 days7-10 days
100 μL$3717-10 days7-10 days
200 μL$5297-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-ZEB1/NIL2A Polyclonal Antibody 2 is a Rabbit antibody targeting ZEB1/NIL2A. Anti-ZEB1/NIL2A Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
Reactivity
Human,Mouse (predicted:Rat,Chicken,Dog,Pig,Cow,Rabbit,Sheep)
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus.
Tissue SpecificityColocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThis gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human ZEB1/NIL2A
Antigen Species
Human
Gene Name
ZEB1
Gene ID
Protein Name
Zinc finger E-box-binding homeobox 1
Uniprot ID
Function
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Chemical Properties
Molecular WeightTheoretical: 124 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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