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AM404
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Catalog No. T39281Cas No. 183718-77-6
Alias AM 404
AM404 is an endocannabinoid reuptake inhibitor, a TRPV(1) activator, a paracetamol metabolite, with neuroprotective and anticancer activity that blocks anandamide transport. AM404 inhibits NFAT and NF-kappaB signaling pathways and impairs migration and invasiveness of neuroblastoma cells, preventing prostaglandin synthesis in activated microglia by inhibiting COX activity.
AM404
😃Good
Catalog No. T39281Alias AM 404Cas No. 183718-77-6
AM404 is an endocannabinoid reuptake inhibitor, a TRPV(1) activator, a paracetamol metabolite, with neuroprotective and anticancer activity that blocks anandamide transport. AM404 inhibits NFAT and NF-kappaB signaling pathways and impairs migration and invasiveness of neuroblastoma cells, preventing prostaglandin synthesis in activated microglia by inhibiting COX activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg（126.4 mM * 100 μL in Ethanol） | $63 | 35 days | |
| 10 mg（126.4 mM * 200 μL in Ethanol） | $113 | 35 days | |
| 50 mg（126.4 mM * 1 mL in Ethanol） | $465 | 35 days | |
| 100 mg（126.4 mM * 2 mL in Ethanol） | $793 | 35 days |
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Concentration:50.0 mg/mL
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Product Introduction
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Chemical Properties
| Description | AM404 is an endocannabinoid reuptake inhibitor, a TRPV(1) activator, a paracetamol metabolite, with neuroprotective and anticancer activity that blocks anandamide transport. AM404 inhibits NFAT and NF-kappaB signaling pathways and impairs migration and invasiveness of neuroblastoma cells, preventing prostaglandin synthesis in activated microglia by inhibiting COX activity. |
| Targets&IC50 | C6 glioma cells:4.9 μM |
| In vitro | At the concentration used to block cellular accumulation of the endogenous cannabinoid anandamide, AM404 nonspecifically inhibited the proliferation of C6 glioma cells, with an IC50 = 4.9 μM for C6 glioma cells. [2] |
| In vivo | Intraperitoneal injections of 1-5 mg/kg AM404 showed dose-dependent anxiolytic-like effects in the elevated cross maze, defensive withdrawal, and separation-induced ultrasonic vocalizations, the three models. Intraperitoneal injection of 2.5-10 mg/kg AM404 resulted in a dose-dependent increase in anandamide levels in the prefrontal cortex, hippocampus and thalamus of adult male Sprague-Dawley rats. [2] |
| Synonyms | AM 404 |
| Molecular Weight | 395.58 |
| Formula | C26H37NO2 |
| Cas No. | 183718-77-6 |
| Smiles | N(C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)C1=CC=C(O)C=C1 |
| Relative Density. | 1.007 g/cm3 (Predicted) |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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