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AM404
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Catalog No. T39281Cas No. 183718-77-6
Alias AM 404
AM404 is an endocannabinoid reuptake inhibitor, a TRPV(1) activator, a paracetamol metabolite, with neuroprotective and anticancer activity that blocks anandamide transport. AM404 inhibits NFAT and NF-kappaB signaling pathways and impairs migration and invasiveness of neuroblastoma cells, preventing prostaglandin synthesis in activated microglia by inhibiting COX activity.
AM404
Copy Product Info😃Good
Catalog No. T39281Alias AM 404Cas No. 183718-77-6
AM404 is an endocannabinoid reuptake inhibitor, a TRPV(1) activator, a paracetamol metabolite, with neuroprotective and anticancer activity that blocks anandamide transport. AM404 inhibits NFAT and NF-kappaB signaling pathways and impairs migration and invasiveness of neuroblastoma cells, preventing prostaglandin synthesis in activated microglia by inhibiting COX activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg（126.4 mM * 100 μL in Ethanol） | $63 | 35 days | 35 days | |
| 10 mg（126.4 mM * 200 μL in Ethanol） | $113 | 35 days | 35 days | |
| 50 mg（126.4 mM * 1 mL in Ethanol） | $465 | 35 days | 35 days | |
| 100 mg（126.4 mM * 2 mL in Ethanol） | $793 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | AM404 is an endocannabinoid reuptake inhibitor, a TRPV(1) activator, a paracetamol metabolite, with neuroprotective and anticancer activity that blocks anandamide transport. AM404 inhibits NFAT and NF-kappaB signaling pathways and impairs migration and invasiveness of neuroblastoma cells, preventing prostaglandin synthesis in activated microglia by inhibiting COX activity. |
| Targets&IC50 | C6 glioma cells:4.9 μM |
| In vitro | At the concentration used to block cellular accumulation of the endogenous cannabinoid anandamide, AM404 nonspecifically inhibited the proliferation of C6 glioma cells, with an IC50 = 4.9 μM for C6 glioma cells. [2] |
| In vivo | Intraperitoneal injections of 1-5 mg/kg AM404 showed dose-dependent anxiolytic-like effects in the elevated cross maze, defensive withdrawal, and separation-induced ultrasonic vocalizations, the three models. Intraperitoneal injection of 2.5-10 mg/kg AM404 resulted in a dose-dependent increase in anandamide levels in the prefrontal cortex, hippocampus and thalamus of adult male Sprague-Dawley rats. [2] |
| Synonyms | AM 404 |
| Molecular Weight | 395.58 |
| Formula | C26H37NO2 |
| Cas No. | 183718-77-6 |
| Smiles | N(C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)C1=CC=C(O)C=C1 |
| Relative Density. | 1.007 g/cm3 (Predicted) |
| Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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