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TD-198946

Name: TD-198946
Brand: TargetMol
SKU: T4193
Price: 72 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4193Cas No. 364762-86-7

Alias TD198946, TD 198946

TD-198946, a potent chondrogenic agent, is a thienoindazole derivative.

TD-198946

😃Good

Catalog No. T4193Alias TD198946, TD 198946Cas No. 364762-86-7

TD-198946, a potent chondrogenic agent, is a thienoindazole derivative.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$72	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$238	In Stock	In Stock
25 mg	$429	In Stock	In Stock
50 mg	$568	In Stock	In Stock
100 mg	$789	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$156	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:Yellow

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COA HNMR

Product Introduction

Bioactivity

Description	TD-198946, a potent chondrogenic agent, is a thienoindazole derivative.
In vitro	In cell and metatarsal organ cultures, TD-198946 markedly induces chondrogenic differentiation without promoting hypertrophy. In ATDC5 cells, TD-198946 induces stronger?Col2a1?promoter activity than insulin. In C3H10T1/2 cells, ATDC5 cells and primary mouse chondrocytes, TD-198946 dose-dependently stimulates endogenous expression of the chondrocyte markers?Acan?and?Col2a1 (maximum effects: 1-10 μM).
In vivo	TD-198946 can prevent and repair degeneration of the articular cartilage by administered directly into the joint space. TD-198946 regulates Runx1 expression, which is downregulated in both mouse and human OA cartilage compared with normal tissue. TD-198946 may prevent the progression of osteoarthritis by acting on the remaining chondrocytes rather than repairing damaged cartilage. Cartilaginous cell-sheets are generated by culturing human mesenchymal stem cells and canine and mouse costal chondrocytes with TD-198946 on temperature-responsive dishes.
Animal Research	For intra-articular injection, TD-198946 is dissolved at 100 nM in a solution of 45% 2-hydropropyl-b-cyclodextrin in saline.Mouse: Each of the prevention and repair models had two groups: (1) TD-198946-treated animals and (2) saline-treated animals. In all the mice tested the left knee joints underwent the operation and the right knee joints are sham-operated. Mice are re-anesthetized and given a 10 μL intra-articular injection of TD-198946 or saline immediately after surgery (prevention model) or 4 weeks following surgery (repair model) every 5 days for 8 or 4 weeks, respectively.
Synonyms	TD198946, TD 198946

Chemical Properties

Molecular Weight	482.55
Formula	C₂₇H₂₂N₄O₃S
Cas No.	364762-86-7
Smiles	Cn1ncc2CCc3c(sc(Oc4ccc(OCc5ccc6ccccc6n5)cc4)c3-c12)C(N)=O
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (103.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0723 mL	10.3616 mL	20.7232 mL	103.6162 mL
5 mM	0.4145 mL	2.0723 mL	4.1446 mL	20.7232 mL
10 mM	0.2072 mL	1.0362 mL	2.0723 mL	10.3616 mL
20 mM	0.1036 mL	0.5181 mL	1.0362 mL	5.1808 mL
50 mM	0.0414 mL	0.2072 mL	0.4145 mL	2.0723 mL
100 mM	0.0207 mL	0.1036 mL	0.2072 mL	1.0362 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc