Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4. 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils. It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | 35 days | $ 265.00 | |
25 μg | 35 days | $ 555.00 | |
50 μg | 35 days | $ 987.00 | |
100 μg | 35 days | $ 1,800.00 |
Description | Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4. 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils. It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively. |
Synonyms | 12-oxo Leukotriene B4 |
Molecular Weight | 334.456 |
Formula | C20H30O4 |
CAS No. | 136696-10-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: Miscible
PBS (pH 7.2): > 1 mg/mL
DMF: Miscible
DMSO: Miscible
You can also refer to dose conversion for different animals. More
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12-oxo Leukotriene B4 136696-10-1 12oxo Leukotriene B4 12 oxo Leukotriene B4 12-oxo Leukotriene B-4 inhibitor inhibit