OX40L/TNFSF4 Protein, Human, Recombinant (mFc)

Name: OX40L/TNFSF4 Protein, Human, Recombinant (mFc)
Brand: TargetMol
SKU: TMPY-04354
Rating: 4.5 (1 reviews)

(Synonyms: TXGP1, tumor necrosis factor (ligand) superfamily, member 4, OX4OL, OX-40L, GP34, CD252, CD134L) Copy Product Info

Synonyms: TXGP1, tumor necrosis factor (ligand) superfamily, member 4, OX4OL, OX-40L, GP34, CD252, CD134L

Catalog No. TMPY-04354 Copy Product Info

OX40L/TNFSF4 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.1 kDa and the accession number is A0A024R937.

Pack Size	Price	USA Stock	Global Stock
5 µg	$55	7-10 days	7-10 days
10 µg	$87	7-10 days	7-10 days
20 µg	$142	7-10 days	7-10 days
50 µg	$277	7-10 days	7-10 days
100 µg	$535	7-10 days	7-10 days
200 µg	$815	7-10 days	7-10 days
500 µg	$1,680	7-10 days	7-10 days
1 mg	$3,480	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its binding ability in a functional ELISA. Immobilized recombinant Human TNFRSF4-His at 10 μg/ml (100 μl/well) can bind human S4-mFc3-TNFSF4 with a linear range of 1.28-20 μg/ml.
Description	OX40L/TNFSF4 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.1 kDa and the accession number is A0A024R937.
Species	Human
Expression System	HEK293 Cells
Tag	N-mFc
Accession Number	P23510
Construction	A DNA sequence encoding the human TNFSF4 (NP_003317.1) (Gln51-Leu183) was expressed with the Fc region of mouse IgG1 at the N-terminus. Predicted N terminal: Asp
Protein Purity	> 90 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	TXGP1, tumor necrosis factor (ligand) superfamily, member 4, OX4OL, OX-40L, GP34, CD252, CD134L
Research Background	OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX40. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

42.1 kDa (predicted); 53.3 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.