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Anti-Nogo Receptor/NgR Antibody
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Catalog No. T9901A-1366 Copy Product Info
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Anti-Nogo Receptor/NgR Antibody is a humanized monoclonal antibody targeting Nogo Receptor 1 (NgR1/RTN4R). NgR1 is a common receptor for CNS myelin-derived inhibitory factors (e.g., Nogo-A, MAG, and OMgp), the activation of which induces growth cone collapse and inhibits axonal regeneration. By specifically binding to NgR1, this antibody blocks the interaction between inhibitory ligands and the receptor, thereby lifting the restriction on neuronal growth and promoting axonal regeneration, compensatory sprouting, and synaptic plasticity. It is a vital tool for researching neural repair in spinal cord injury, stroke, and multiple sclerosis.
Anti-Nogo Receptor/NgR Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $377 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-Nogo Receptor/NgR Antibody is a humanized monoclonal antibody targeting Nogo Receptor 1 (NgR1/RTN4R). NgR1 is a common receptor for CNS myelin-derived inhibitory factors (e.g., Nogo-A, MAG, and OMgp), the activation of which induces growth cone collapse and inhibits axonal regeneration. By specifically binding to NgR1, this antibody blocks the interaction between inhibitory ligands and the receptor, thereby lifting the restriction on neuronal growth and promoting axonal regeneration, compensatory sprouting, and synaptic plasticity. It is a vital tool for researching neural repair in spinal cord injury, stroke, and multiple sclerosis. |
| In vitro | In cell-based neurite outgrowth assays, Anti-Nogo Receptor/NgR Antibody effectively blocks the binding of myelin-associated inhibitors (Nogo, MAG, and OMgp) to NgR1-expressing neurons, significantly reversing growth cone collapse and promoting neurite extension in primary DRG or cortical neurons [1][2]. |
| In vivo | In pharmacological studies using rat models of spinal cord hemisection or ischemic stroke, intrathecal or systemic administration of Anti-Nogo Receptor/NgR Antibody (such as mAb 50) led to marked enhancement of functional locomotor recovery, accompanied by increased axonal sprouting and structural plasticity within the lesioned central nervous system [1][2]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | NogoReceptor/NgR |
| Isotype | IgG2SA |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Anti-Nogo Receptor/NgR Antibody in vivo | Anti-Nogo Receptor/NgR Antibody in vitro
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