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LY2444296

Name: LY2444296
Brand: TargetMol
SKU: T11909
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11909Cas No. 1346133-11-6

Alias FP3FBZ

LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).

LY2444296

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Purity: 99.18%

Catalog No. T11909Alias FP3FBZCas No. 1346133-11-6

LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	-	In Stock
10 mg	$74	-	In Stock
25 mg	Preferential	-	In Stock
50 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.18%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).
Targets&IC50	κ opioid receptor:ki： ~1 nM
In vivo	LY2444296 reduces anxiety-like and depressive-like behaviors, and CORT release, in rats tested after chronic extended access cocaine self-administration. In cocaine-naïve adult male Sprague Dawley rats, LY2444296 (3 mg/kg; i.p.) prevents behavioral and neuroendocrine effects caused by U69,593[2].
Synonyms	FP3FBZ

Chemical Properties

Molecular Weight	408.44
Formula	C₂₄H₂₂F₂N₂O₂
Cas No.	1346133-11-6
Smiles	NC(=O)c1ccc(Oc2ccc(CN3CCC[C@H]3c3cccc(F)c3)cc2)c(F)c1
Relative Density.	1.276 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 25.2 mg/mL (61.7 mM), Sonication is recommended.

Methanol: 5 mg/mL (12.24 mM), Sonication is recommended.

DMSO: 60 mg/mL (146.9 mM), Sonication is recommended.

Solution Preparation Table

Methanol/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4483 mL	12.2417 mL	24.4834 mL	122.4170 mL
5 mM	0.4897 mL	2.4483 mL	4.8967 mL	24.4834 mL
10 mM	0.2448 mL	1.2242 mL	2.4483 mL	12.2417 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1224 mL	0.6121 mL	1.2242 mL	6.1209 mL
50 mM	0.0490 mL	0.2448 mL	0.4897 mL	2.4483 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0245 mL	0.1224 mL	0.2448 mL	1.2242 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc