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(S,S,S)-AHPC hydrochloride

Name: (S,S,S)-AHPC hydrochloride
Brand: TargetMol
SKU: T13877
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13877Cas No. 2115897-23-7

Alias (S,S,S)-VH032-NH2 hydrochloride

(S,S,S)-AHPC hydrochloride ((S,S,S)-VH032-NH2 hydrochloride) is a VHL amino building block and ligand used as a negative control for (S,R,S)-AHPC. It is based on VH032 and is employed in the recruitment of the VHL protein.

(S,S,S)-AHPC hydrochloride

🥰Excellent

Purity: 98.22%

Catalog No. T13877Alias (S,S,S)-VH032-NH2 hydrochlorideCas No. 2115897-23-7

Pack Size	Price	Availability
10 mg	$38	In Stock
25 mg	$65	In Stock
50 mg	$98	In Stock
100 mg	$158	In Stock
1 mL x 10 mM (in DMSO)	$38	In Stock

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Batch Information

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Purity:98.22%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	(S,S,S)-AHPC hydrochloride ((S,S,S)-VH032-NH2 hydrochloride) is a VHL amino building block and ligand used as a negative control for (S,R,S)-AHPC. It is based on VH032 and is employed in the recruitment of the VHL protein.
In vitro	VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.
Synonyms	(S,S,S)-VH032-NH2 hydrochloride

Chemical Properties

Molecular Weight	467.02
Formula	C₂₂H₃₁ClN₄O₃S
Cas No.	2115897-23-7
Smiles	Cl.Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 99 mg/mL (211.98 mM), Sonication is recommended.

DMSO: 60 mg/mL (128.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.1412 mL	10.7062 mL	21.4124 mL	107.0618 mL
5 mM	0.4282 mL	2.1412 mL	4.2825 mL	21.4124 mL
10 mM	0.2141 mL	1.0706 mL	2.1412 mL	10.7062 mL
20 mM	0.1071 mL	0.5353 mL	1.0706 mL	5.3531 mL
50 mM	0.0428 mL	0.2141 mL	0.4282 mL	2.1412 mL
100 mM	0.0214 mL	0.1071 mL	0.2141 mL	1.0706 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc