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CCG 203769

Name: CCG 203769
Brand: TargetMol
SKU: T10705
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10705Cas No. 410074-60-1

Alias Thiadiazolidinone (TDZD) deriv. 6, RGS4 inhibitor 11b, 4-butyl-2-ethyl-1,2,4-thiadiazolidine-3,5-dione

CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction.

CCG 203769

🥰Excellent

Purity: 99.88%

Catalog No. T10705Alias Thiadiazolidinone (TDZD) deriv. 6, RGS4 inhibitor 11b, 4-butyl-2-ethyl-1,2,4-thiadiazolidine-3,5-dioneCas No. 410074-60-1

CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction.

Pack Size	Price	Availability
1 mg	$81	In Stock
5 mg	$197	In Stock
10 mg	$278	In Stock
25 mg	$493	In Stock
50 mg	$692	In Stock
100 mg	$993	In Stock
500 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$217	In Stock

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Purity:99.88%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction.
Targets&IC50	RGS4:17 nM, RGS19:140 nM, RGS8:79 μM, GSK-3β:5.4 μM, RGS16:6 μM
In vitro	CCG 203769 displays dramatic selectivity (8- to >5000-fold) for RGS4 over other RGS proteins with IC50s of 140 nM, 6 μM, and 79 μM for RGS19, RGS16, and RGS8. CCG 203769 inhibits GSK-3β with an IC50 of 5 μM. CCG 203769 enhances Gαq-dependent cellular Ca2+ signaling in an RGS4-dependent manner and inhibits RGS/Gαo binding in an RGS-selective manner. CCG 203769 also blocks the GTPase accelerating protein (GAP) activity of RGS4. CCG 203769 inhibits the effect of GTP hydrolysis stimulated by RGS4 with an IC50<1 μM in single-turnover and steady-state GTPase experiments[1].
In vivo	CCG 203769 (10 mg/kg, i.v.), administered immediately prior to Carbamoylcholine chloride(0.1 mg/kg, i.p.), significantly potentiates the bradycardic effect. CCG 203769 (1-10 mg/kg) reverses the increased hang time caused by raclopride administration in rats. CCG 203769 (0.1-10 mg/kg) reverses the raclopride-induced paw drag in mice[1].
Synonyms	Thiadiazolidinone (TDZD) deriv. 6, RGS4 inhibitor 11b, 4-butyl-2-ethyl-1,2,4-thiadiazolidine-3,5-dione

Chemical Properties

Molecular Weight	202.27
Formula	C₈H₁₄N₂O₂S
Cas No.	410074-60-1
Smiles	CCCCn1c(=O)sn(CC)c1=O
Relative Density.	1.179 g/cm3 (Predicted)
Color	Transparent
Appearance	Liquid

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (247.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9439 mL	24.7194 mL	49.4389 mL	247.1943 mL
5 mM	0.9888 mL	4.9439 mL	9.8878 mL	49.4389 mL
10 mM	0.4944 mL	2.4719 mL	4.9439 mL	24.7194 mL
20 mM	0.2472 mL	1.2360 mL	2.4719 mL	12.3597 mL
50 mM	0.0989 mL	0.4944 mL	0.9888 mL	4.9439 mL
100 mM	0.0494 mL	0.2472 mL	0.4944 mL	2.4719 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc