Shopping Cart

Your shopping cart is currently empty

Baxdrostat

Name: Baxdrostat
Brand: TargetMol
SKU: T61373
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T61373Cas No. 1428652-17-8

Baxdrostat is an aldosterone synthase inhibitor.

Baxdrostat

Copy Product Info

😃Good

Purity: 99.8%

Catalog No. T61373Cas No. 1428652-17-8

Baxdrostat is an aldosterone synthase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$263	In Stock	In Stock
25 mg	$436	In Stock	In Stock
50 mg	$612	In Stock	In Stock
100 mg	$786	-	In Stock
200 mg	$1,090	-	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.8%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Baxdrostat AI Summary

Baxdrostat demonstrates significant bioactivity in cellular enzyme assays targeting CYP11B1 and CYP11B2. The compound was evaluated for its effect on the enzymatic activity of these enzymes using 11-Deoxycorticosterone and 11-Deoxycortisol as substrates. The assays involved transfecting the expression plasmids into G-402 cells, followed by selection for specific resistance markers. The production of Aldosterone and Cortisol, as the expected products for CYP11B2 and CYP11B1 respectively, was analyzed. The compound exhibited EC50 values of 14.0 nM for CYP11B1 and 980.0 nM for CYP11B2, demonstrating its potency in modulating these enzymatic activities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Baxdrostat is an aldosterone synthase inhibitor.

Chemical Properties

Molecular Weight	363.45
Formula	C₂₂H₂₅N₃O₂
Cas No.	1428652-17-8
Smiles	CCC(=O)N[C@@H]1CCCc2c1cncc2-c1ccc2N(C)C(=O)CCc2c1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1mg/mL (insoluble)

DMSO: 90 mg/mL (247.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7514 mL	13.7571 mL	27.5141 mL	137.5705 mL
5 mM	0.5503 mL	2.7514 mL	5.5028 mL	27.5141 mL
10 mM	0.2751 mL	1.3757 mL	2.7514 mL	13.7571 mL
20 mM	0.1376 mL	0.6879 mL	1.3757 mL	6.8785 mL
50 mM	0.0550 mL	0.2751 mL	0.5503 mL	2.7514 mL
100 mM	0.0275 mL	0.1376 mL	0.2751 mL	1.3757 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc