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Abetimus

Catalog No. T83217 CAS 167362-48-3

Synonyms: LJP 394 free base

Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering research potential for systemic lupus erythematosus [1].

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Abetimus, CAS 167362-48-3

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Description	Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering research potential for systemic lupus erythematosus [1].
In vitro	Administration of Abetimus (LJP 394 free base) is believed to decrease circulating anti-double-stranded DNA antibodies (anti-dsDNA Abs) through at least two mechanisms.
In vivo	Abetimus (LJP 394 free base) demonstrates efficacy in diminishing anti-dsDNA-mediated disease manifestations in the male BXSB mouse, which serves as a model for systemic lupus. Administration of Abetimus at dosages between 3-300 μg/mouse intravenously twice weekly from approximately nine weeks of age resulted in significantly reduced anti-dsDNA antibody titers, a decreased number of anti-dsDNA-secreting spleen cells, and improved renal histopathology compared to untreated controls [2]. Additionally, the pharmacokinetic profile of Abetimus in mice displays a half-life of 40 minutes to 1 hour [1].

Synonyms	LJP 394 free base
Molecular Weight	318.28
Formula	C11H18N4O7
CAS No.	167362-48-3

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Abetimus 167362-48-3 LJP 394 free base inhibitor inhibit

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