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Abetimus

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Catalog No. T83217Cas No. 167362-48-3
Alias LJP 394 free base

Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering research potential for systemic lupus erythematosus [1].

Abetimus

Abetimus

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😃Good
Catalog No. T83217Alias LJP 394 free baseCas No. 167362-48-3
Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering research potential for systemic lupus erythematosus [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mgInquiry8-10 weeks8-10 weeks
50 mgInquiry8-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Bioactivity
Description
Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering research potential for systemic lupus erythematosus [1].
In vitro
The administration of Abetimus (LJP 394 free base) is believed to reduce circulating anti-double-stranded DNA antibodies (anti-dsDNA Abs) via at least two mechanisms.
In vivo
Abetimus (LJP 394 free base) effectively reduces anti-dsDNA-mediated disease symptoms in male BXSB mice, a systemic lupus model. Administering Abetimus at 3-300 μg/mouse intravenously twice weekly from around nine weeks of age significantly lowered anti-dsDNA antibody levels, decreased anti-dsDNA-secreting spleen cells, and improved renal histopathology compared to untreated controls [2]. Additionally, Abetimus exhibits a pharmacokinetic half-life of 40 minutes to 1 hour in mice [1].
SynonymsLJP 394 free base
Chemical Properties
Molecular Weight318.28
FormulaC11H18N4O7
Cas No.167362-48-3
SmilesO=C(C1CC([C-](C(C1)=O)C(CC)=O)=O)[O-].[0.5Ca2+].[0.5Ca2+]
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

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