Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BRD4 BD2. Additionally, PROTAC BRD4 Degrader-15 demonstrates potent degradation activity against the BRD4 protein in PC3 prostate cancer cells.
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Description | PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BRD4 BD2. Additionally, PROTAC BRD4 Degrader-15 demonstrates potent degradation activity against the BRD4 protein in PC3 prostate cancer cells. |
Targets&IC50 | BRD4 BD2:8.1 nM (IC50), BRD4 BD1:7.2 nM (IC50) |
In vitro | PROTAC BRD4 Degrader-15 (compound 13) effectively reduces MYC gene expression in MV4-11 AML cells within 4 hours, demonstrating significant potency with an IC50 of 15 nM[1]. Additionally, over a period of 6 days, this compound substantially inhibits the growth of HL-60 and PC3-S1 cells, displaying IC50 values of 4.2 nM and 91 nM, respectively[1]. |
Synonyms | PROTAC BRD4 Degrader-15 |
Molecular Weight | 1149.3 |
Formula | C57H62F2N10O10S2 |
CAS No. | 2417370-67-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PROTAC BRD4 Degrader-15 2417370-67-1 PROTAC BRD4 Degrader15 PROTAC BRD-4 Degrader-15 PROTAC BRD4 Degrader 15 inhibitor inhibit