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hDHODH-IN-5

🥰Excellent
Catalog No. T11029Cas No. 2029049-77-0
Alias DHODH-IN-7

hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).

hDHODH-IN-5

hDHODH-IN-5

🥰Excellent
Purity: 99.55%
Catalog No. T11029Alias DHODH-IN-7Cas No. 2029049-77-0
hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$77In StockIn Stock
5 mg$169In StockIn Stock
10 mg$246In StockIn Stock
25 mg$396In StockIn Stock
50 mg$589In StockIn Stock
100 mg$839In StockIn Stock
1 mL x 10 mM (in DMSO)$185In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.55%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).
In vitro
hDHODH-IN-5 induces differentiation in ER-HOX-GFP, THP1, and U937 human AML cell lines with EC50s of 3.6, 2.7, and 2.5 μM, respectively[1].
SynonymsDHODH-IN-7
Chemical Properties
Molecular Weight390.4
FormulaC21H21F3N2O2
Cas No.2029049-77-0
SmilesN(C(CCNC(=O)C1=CC=C(C(F)(F)F)C=C1)=O)[C@H]2C=3C(CCC2)=CC=CC3
Relative Density.1.29 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mg/mL (25.61 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5615 mL12.8074 mL25.6148 mL128.0738 mL
5 mM0.5123 mL2.5615 mL5.1230 mL25.6148 mL
10 mM0.2561 mL1.2807 mL2.5615 mL12.8074 mL
20 mM0.1281 mL0.6404 mL1.2807 mL6.4037 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

hDHODH-IN-5hDHODH
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