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Anti-Frizzled 10/CD350 Polyclonal Antibody
😃Good
Catalog No. TMAB-06166
Anti-Frizzled 10/CD350 Polyclonal Antibody is a Rabbit antibody targeting Frizzled 10/CD350. Anti-Frizzled 10/CD350 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-Frizzled 10/CD350 Polyclonal Antibody
Anti-Frizzled 10/CD350 Polyclonal Antibody
😃Good
Catalog No. TMAB-06166
Anti-Frizzled 10/CD350 Polyclonal Antibody is a Rabbit antibody targeting Frizzled 10/CD350. Anti-Frizzled 10/CD350 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Frizzled 10/CD350 Polyclonal Antibody is a Rabbit antibody targeting Frizzled 10/CD350. Anti-Frizzled 10/CD350 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane. |
| Tissue Specificity | Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled as well as several secreted mammalian frizzled-related proteins (FRPs) have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. Upregulation of frizzled-10 mRNA in human cells may lead to carcinogenesis through Wnt- Beta-catenin-TCF signaling pathway activation. Frizzled-10 has been found to be upregulated in HeLa S3, NT2, TMK1 and MKN74 cancer cell lines as well as in colorectal and breast cancer. |
| Immunogen | KLH conjugated synthetic peptide: human Frizzled 10/CD350 |
| Antigen Species | Human |
| Gene Name | FZD10 |
| Gene ID | |
| Protein Name | Frizzled-10 |
| Uniprot ID | |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| Molecular Weight | Theoretical: 68 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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