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YB-0158

Catalog No. T38519 CAS 1144043-83-3

Synonyms: Wnt pathway inhibitor 2, YB-0158

YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a reverse-turn agent, inducing apoptosis in CRC cells and displaying strong anti-cancer activities.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

YB-0158, CAS 1144043-83-3

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	$ 697.00
10 mg	Inquiry	$ 1,120.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a reverse-turn agent, inducing apoptosis in CRC cells and displaying strong anti-cancer activities.
Targets&IC50	Wnt:6.2 μM (IC50)
In vitro	YB-0158, at concentrations of 0.2 μM and 0.5 μM over a 48-hour period, significantly enhances apoptosis in CRC cells, as evidenced by activated Caspase-3/7 detection assays[1]. Additionally, a 0.3 μM concentration of YB-0158 markedly reduces CBP recruitment at the LGR5 and MYC promoter regions of Wnt/beta-Catenin target genes in HT29 cells, compared to a DMSO control[1].
In vivo	YB-0158 exhibits an effective concentration (EC 50) of 1.64 μM in MC38 cells cultured in vitro. In vivo experiments utilizing C57BL/6 mice with MC38 cell-derived tumors demonstrate that YB-0158 administered intraperitoneally (IP) at a dose of 100 mg/kg does not significantly alter primary tumor size compared to saline-treated controls[2].

Synonyms	Wnt pathway inhibitor 2, YB-0158
Molecular Weight	705.619
Formula	C32H34N7Na2O7P
CAS No.	1144043-83-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Masibag AN, Bergin CJ, Haebe JR, et al. Pharmacological targeting of Sam68 functions in colorectal cancer stem cells. iScience. 2021;24(12):103442.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

YB-0158 1144043-83-3 YB 0158 YB0158 Wnt pathway inhibitor 2 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.