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YB-0158
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Catalog No. T38519Cas No. 1144043-83-3
Alias YB-0158, Wnt pathway inhibitor 2
YB-0158 (Wnt pathway inhibitor 2) is a potent peptidomimetic compound that targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. As a reverse-turn agent, it induces apoptosis in CRC cells and exhibits strong anti-cancer activity.
YB-0158
Copy Product Info😃Good
Catalog No. T38519Alias YB-0158, Wnt pathway inhibitor 2Cas No. 1144043-83-3
YB-0158 (Wnt pathway inhibitor 2) is a potent peptidomimetic compound that targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. As a reverse-turn agent, it induces apoptosis in CRC cells and exhibits strong anti-cancer activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $697 | Inquiry | Inquiry | |
| 10 mg | $1,120 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | YB-0158 (Wnt pathway inhibitor 2) is a potent peptidomimetic compound that targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. As a reverse-turn agent, it induces apoptosis in CRC cells and exhibits strong anti-cancer activity. |
| Targets&IC50 | Wnt:6.2 μM (IC50) |
| In vitro | YB-0158, at concentrations of 0.2 μM and 0.5 μM over a 48-hour period, significantly enhances apoptosis in CRC cells, as evidenced by activated Caspase-3/7 detection assays[1]. Additionally, a 0.3 μM concentration of YB-0158 markedly reduces CBP recruitment at the LGR5 and MYC promoter regions of Wnt/beta-Catenin target genes in HT29 cells, compared to a DMSO control[1]. |
| In vivo | YB-0158 exhibits an effective concentration (EC 50) of 1.64 μM in MC38 cells cultured in vitro. In vivo experiments utilizing C57BL/6 mice with MC38 cell-derived tumors demonstrate that YB-0158 administered intraperitoneally (IP) at a dose of 100 mg/kg does not significantly alter primary tumor size compared to saline-treated controls[2]. |
| Synonyms | YB-0158, Wnt pathway inhibitor 2 |
| Molecular Weight | 703.59 |
| Formula | C32H32N7Na2O7P |
| Cas No. | 1144043-83-3 |
| Smiles | [H][C@]12CN(C([C@@H](N1C(CN(N2C(NCc3ccccc3)=O)CC=C)=O)Cc4ccc(OP([O-])([O-])=O)cc4)=O)Cc(ccc5)c6c5cn[nH]6.[Na+].[Na+] |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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