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(E)-3-(4-Methoxyphenyl)acrylic acid
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Catalog No. T41095Cas No. 943-89-5
(E)-3-(4-Methoxyphenyl)acrylic acid is a small molecule compound isolated from the rhizome of Etlingera pavieana (Pierre ex Gagnep.) R. M. Sm. It is a novel α-glucosidase inhibitor with hepatoprotective, antiamnesic, and cognitive enhancement activities, and it can be used to lower blood pressure sugar.
(E)-3-(4-Methoxyphenyl)acrylic acid
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Purity: 99.99%
Catalog No. T41095Cas No. 943-89-5
(E)-3-(4-Methoxyphenyl)acrylic acid is a small molecule compound isolated from the rhizome of Etlingera pavieana (Pierre ex Gagnep.) R. M. Sm. It is a novel α-glucosidase inhibitor with hepatoprotective, antiamnesic, and cognitive enhancement activities, and it can be used to lower blood pressure sugar.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 g | $29 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.99%
Appearance:Solid
Color:White
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Product Introduction
(E)-3-(4-Methoxyphenyl)acrylic acid AI Summary
(E)-3-(4-Methoxyphenyl)acrylic acid exhibits a wide range of bioactivities across different molecular targets and biological systems. It inhibits alpha-glucosidase activity with IC50 values ranging from 40,000 nM to 44,000 nM and shows potential as an antifungal agent against Saccharomyces cerevisiae, Candida albicans, and Pityrosporum ovale with minimum inhibitory concentrations (MICs) of 100 µg/mL, 200 µg/mL, and >800 µg/mL, respectively. This compound also inhibits nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages with an IC50 value greater than 100,000 nM and a 27% inhibition rate at 100 µM concentration. It exhibits tyrosinase inhibition with an IC50 value of 410,000 nM, indicating moderate activity, and significant inhibitory effects at various concentrations.
Furthermore, (E)-3-(4-Methoxyphenyl)acrylic acid demonstrates herbicidal activity against velvetleaf by affecting seed germination at different concentrations, being inhibitory at higher concentrations and slightly stimulatory at lower ones. It also shows herbicidal activity against radish seeds with high inhibition rates at 50-200 ppm. The compound has antiviral potential against SARS-CoV-2 with modest inhibition rates in cytotoxicity assays on Caco-2 and VERO-6 cells. Additionally, it exhibits minimal activity against human HDAC6, TAS2R39, and various carbonic anhydrases, with specific IC50 values for carbonic anhydrases being 760,000 nM and 850,000 nM.
Overall, (E)-3-(4-Methoxyphenyl)acrylic acid shows versatile biological activities ranging from enzymatic inhibition, antimicrobial effects, herbicidal action, to potential antiviral properties..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (E)-3-(4-Methoxyphenyl)acrylic acid is a small molecule compound isolated from the rhizome of Etlingera pavieana (Pierre ex Gagnep.) R. M. Sm. It is a novel α-glucosidase inhibitor with hepatoprotective, antiamnesic, and cognitive enhancement activities, and it can be used to lower blood pressure sugar. |
| Molecular Weight | 178.18 |
| Formula | C10H10O3 |
| Cas No. | 943-89-5 |
| Smiles | C(=C/C(O)=O)\C1=CC=C(OC)C=C1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (280.62 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.22 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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