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Meropenem

Name: Meropenem
Brand: TargetMol
SKU: T0224
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: SM 7338) Copy Product Info

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Synonyms: SM 7338

Catalog No. T0224 Copy Product Info

Purity: 99.71%

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Meropenem (SM 7338) is a synthetic carbapenem antibiotic with broad-spectrum antibacterial activity. It exerts a bactericidal effect by inhibiting the synthesis of peptidoglycan in the bacterial cell wall and is active against a wide range of Gram-positive, Gram-negative, and anaerobic bacteria. Meropenem is active against both susceptible and resistant Neisseria gonorrhoeae (MIC values of 0.02–0.06 mg/mL), Haemophilus influenzae (MIC: 0.03–0.12 mg/mL), and Klebsiella pneumoniae (MIC: 0.015–0.12 mg/mL). Meropenem can be used for constructing bacterial infection models and screening for antimicrobial activity.

Cas No. 96036-03-2

Pack Size	Price	USA Stock	Global Stock
50 mg	$42	In Stock	In Stock
100 mg	$58	In Stock	In Stock
200 mg	$81	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.71%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Meropenem (SM 7338) is a synthetic carbapenem antibiotic with broad-spectrum antibacterial activity. It exerts a bactericidal effect by inhibiting the synthesis of peptidoglycan in the bacterial cell wall and is active against a wide range of Gram-positive, Gram-negative, and anaerobic bacteria. Meropenem is active against both susceptible and resistant Neisseria gonorrhoeae (MIC values of 0.02–0.06 mg/mL), Haemophilus influenzae (MIC: 0.03–0.12 mg/mL), and Klebsiella pneumoniae (MIC: 0.015–0.12 mg/mL). Meropenem can be used for constructing bacterial infection models and screening for antimicrobial activity.
Targets & IC50	E. coli:0.19 µg/mL (MIC), N. gonorrhoeae:0.02-0.06 mg/mL (MIC), H. ducreyi:0.015-0.12 mg/mL (MIC), K. pneumoniae isolates:⩽ 32 mg/L (MIC), H. influenzae:0.03-0.12 mg/mL (MIC)
In vitro	Methods: Clinical isolates of NDM-1-producing Escherichia coli ZC-YN3, along with strains producing NDM-5 and NDM-9, were tested against monotherapy with Meropenem or Magnolol, or combination therapy with Meropenem + Magnolol (32 μg/mL) to determine the minimum inhibitory concentration (MIC). Results: Meropenem monotherapy MIC: 16 μg/mL (against ZC-YN3); Magnolol monotherapy MIC: >1024 μg/mL (no direct antibacterial activity); Meropenem + Magnolol combination MIC: 4 μg/mL (against ZC-YN3), representing a 4-fold reduction. [1] Methods: Human primary alveolar epithelial cells (HPAEpiC) were infected with PAO1 strain after mechanical stretching simulated by the FlexCell system. Drugs (meropenem at 5×MIC and 0.5×MIC) were added 2 hours post-infection. Bacterial load was assessed at 4 and 8 hours post-infection. Results: Meropenem effectively reduced bacterial load. [2]
In vivo	Methods: C57BL/6J mice were mechanically ventilated and infected with PAO1 strain via tracheal inoculation. Meropenem monotherapy was administered via intraperitoneal injection at 4 hours and 16 hours post-infection. Results: Meropenem monotherapy significantly reduced bacterial load in both the lungs and systemic tissues [2].
Synonyms	SM 7338
Kinase Assay	Complementation of SCR7 Inhibition with Puri?ed Ligase IV: Complementation experiment is carried out by adding increasing concentrations of puri?ed Ligase IV/XRCC4 complex (30, 60, and 120 fmol) along with the oligomeric DNA substrates (5' compatible and 5'-5' noncompatible ends) to the SCR7-treatedextracts. Reactions are incubated for 2 h at 25℃. The reaction products are then resolved on 8% denaturing PAGE. The gel is dried and exposed and the signal is detected with a PhosphorImager and analyzed with Multi Gauge (V3.0) software.

Chemical Properties

Molecular Weight	383.46
Formula	C₁₇H₂₅N₃O₅S
Cas No.	96036-03-2
Smiles	C(O)(=O)C=1N2[C@@]([C@@]([C@@H](C)O)(C2=O)[H])([C@@H](C)C1S[C@H]3C[C@@H](C(N(C)C)=O)NC3)[H]
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (260.78 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 5 mg/mL (13.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6078 mL	13.0392 mL	26.0783 mL	130.3917 mL
5 mM	0.5216 mL	2.6078 mL	5.2157 mL	26.0783 mL
10 mM	0.2608 mL	1.3039 mL	2.6078 mL	13.0392 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1304 mL	0.6520 mL	1.3039 mL	6.5196 mL
50 mM	0.0522 mL	0.2608 mL	0.5216 mL	2.6078 mL
100 mM	0.0261 mL	0.1304 mL	0.2608 mL	1.3039 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc