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Noladin ether

Name: Noladin ether
Brand: TargetMol
SKU: T38007
Rating: 4.5 (1 reviews)

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Catalog No. T38007Cas No. 222723-55-9

Alias 2-arachidonyl glyceryl ether, 2-AG ether

Noladin ether (2-AG ether) is a selective and potent cannabinoid CB1 receptor agonist, reducing sensory nerve transmission in rat mesenteric artery beds through a non-CB1/CB2 G(i/o) receptor pathway in a concentration-dependent manner.

Noladin ether

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Catalog No. T38007Alias 2-arachidonyl glyceryl ether, 2-AG etherCas No. 222723-55-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$133	35 days	35 days
5 mg	$548	35 days	35 days
10 mg	$983	35 days	35 days
25 mg	$1,980	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Liquid

Color:Transparent

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COA

Product Introduction

Bioactivity

Description	Noladin ether (2-AG ether) is a selective and potent cannabinoid CB1 receptor agonist, reducing sensory nerve transmission in rat mesenteric artery beds through a non-CB1/CB2 G(i/o) receptor pathway in a concentration-dependent manner.
Targets&IC50	CB1:21.2 nM (Ki), CB2:>3 mM (Ki)
In vitro	In the porcine anterior segment perfusion organ culture model, Noladin ether (3, 30, 300 nM) treatment resulted in a dependent increase in the concentration of aqueous outflow facilities. Treatment of trabecular reticulum cells with Noladin ether (30 nM) can activate p42/44 MAP kinase, and cause the trabecular reticulum cells to become round, actin stress fibers to decrease, and adhesion plaques to decrease. [1]
In vivo	Intraperitoneal injection of Noladin ether (0.5, 1.0, and 2.0 mg/kg) in male rats increased food intake dose-dependently by affecting CB (1) receptors. [2]
Synonyms	2-arachidonyl glyceryl ether, 2-AG ether

Chemical Properties

Molecular Weight	364.56
Formula	C₂₃H₄₀O₃
Cas No.	222723-55-9
Smiles	C(OCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)(CO)CO
Relative Density.	0.948 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol:PBS(pH 7.2) (1:1): 500 μg/mL, Sonication is recommended.

PBS (pH 7.2): < 1 mg/mL (insoluble)

DMF: 8 mg/mL (21.94 mM), Sonication is recommended.

DMSO: 8 mg/mL (21.94 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble)

Solution Preparation Table

DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7430 mL	13.7152 mL	27.4303 mL	137.1516 mL
5 mM	0.5486 mL	2.7430 mL	5.4861 mL	27.4303 mL
10 mM	0.2743 mL	1.3715 mL	2.7430 mL	13.7152 mL
20 mM	0.1372 mL	0.6858 mL	1.3715 mL	6.8576 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc