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Malotilate

Name: Malotilate
Brand: TargetMol
SKU: T6576
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6576Cas No. 59937-28-9

Alias NKK 105, Malotilatum, Kantec

Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.

Malotilate

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Purity: 99.80%

Catalog No. T6576Alias NKK 105, Malotilatum, KantecCas No. 59937-28-9

Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$48	In Stock	In Stock
50 mg	$68	In Stock	In Stock
100 mg	$98	In Stock	In Stock
500 mg	$238	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.80%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Malotilate AI Summary

Malotilate exhibits a diverse range of bioactivities across multiple assays and biological targets. It acts as a potent inhibitor of human tyrosyl-DNA phosphodiesterase 1, with inhibition potencies ranging from 18.37 to 56.234 nM. Furthermore, it shows significant efficacy against Plasmodium falciparum strains (3D7 and DD2), with potencies as low as 0.7 nM. In anti-Ebola virus screens, it demonstrates moderate to strong inhibitory effects, with AC50 values between 14.13 µM and 44.67 µM. Regarding SARS-CoV-2, Malotilate inhibits cell viability in Vero E6 cells infected with the virus (strain BavPat1) at a low MOI (0.002) with an inhibition index of 0.2262 after 72 hours. It also inhibits SARS-CoV-2 3CL-Pro protease activity by 23.6% at a 20 µM concentration and reduces SARS-CoV-2-induced cytotoxicity in Vero E6 cells by 0.28% at 10 µM after 48 hours. Additionally, Malotilate shows moderate binding affinity and bioactivity in various in vitro assays, notably displaying moderate inhibition with an AC50 value of 15000.0 nM in the assay targeting rat Gabra1. However, it generally exhibits binding affinities with AC50 values greater than 30000.0 nM across multiple assays for different biological targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.
Targets&IC50	5-LOX:4.7 μM (IC50)
In vitro	Malotilate caused a significant decrease in the invasion of C-SST-2 cells in RLE monolayers.Malotilate inhibited the increased permeability of RLE monolayers by serum starvation. By enhancing the intercellular contact of endothelial cells, Malotilate prevented the invasion of tumor cells into the vascular endothelium and inhibited tumor metastasis. In multilayer cultures, Malotilate (0.1-100 μM) concentration-dependently increased collagenase activity but did not affect monolayer cells. In damaged multilayer cultures, Malotilate increased MMP-1 and MMP-3 secretion, also without affecting monolayer cells.
In vivo	Malotilate caused a significant decrease in the invasion of C-SST-2 cells in RLE monolayers.Malotilate inhibited the increased permeability of RLE monolayers by serum starvation. By enhancing the intercellular contact of endothelial cells, Malotilate prevented the invasion of tumor cells into the vascular endothelium and inhibited tumor metastasis. In multilayer cultures, Malotilate (0.1-100 μM) concentration-dependently increased collagenase activity but did not affect monolayer cells. In damaged multilayer cultures, Malotilate increased MMP-1 and MMP-3 secretion, also without affecting monolayer cells.
Synonyms	NKK 105, Malotilatum, Kantec

Chemical Properties

Molecular Weight	288.38
Formula	C₁₂H₁₆O₄S₂
Cas No.	59937-28-9
Smiles	C(C(OC(C)C)=O)(C(OC(C)C)=O)=C1SC=CS1
Relative Density.	1.3727 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 58 mg/mL (201.12 mM), Sonication is recommended.

DMSO: 55 mg/mL (190.72 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.4676 mL	17.3382 mL	34.6765 mL	173.3823 mL
5 mM	0.6935 mL	3.4676 mL	6.9353 mL	34.6765 mL
10 mM	0.3468 mL	1.7338 mL	3.4676 mL	17.3382 mL
20 mM	0.1734 mL	0.8669 mL	1.7338 mL	8.6691 mL
50 mM	0.0694 mL	0.3468 mL	0.6935 mL	3.4676 mL
100 mM	0.0347 mL	0.1734 mL	0.3468 mL	1.7338 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc