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α-Viniferin
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Catalog No. TN1378Cas No. 62218-13-7
Alias ALPHA-VINIFERIN
α-Viniferin known as 2-arylbenzofuran flavonoids, that are inhibitors of prostaglandin H2 synthetase. α-Viniferin has anti-Alzheimer's disease, anti-tuberculosis, anti-tumor, anti-inflammation, anti-diabetes and other pharmacological activitie
α-Viniferin
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Purity: 99.91%
Catalog No. TN1378Alias ALPHA-VINIFERINCas No. 62218-13-7
α-Viniferin known as 2-arylbenzofuran flavonoids, that are inhibitors of prostaglandin H2 synthetase. α-Viniferin has anti-Alzheimer's disease, anti-tuberculosis, anti-tumor, anti-inflammation, anti-diabetes and other pharmacological activitie
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $129 | - | In Stock | |
| 5 mg | $328 | - | In Stock | |
| 10 mg | $562 | - | In Stock | |
| 25 mg | $889 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.91%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | α-Viniferin known as 2-arylbenzofuran flavonoids, that are inhibitors of prostaglandin H2 synthetase. α-Viniferin has anti-Alzheimer's disease, anti-tuberculosis, anti-tumor, anti-inflammation, anti-diabetes and other pharmacological activitie |
| Targets&IC50 | Mycobacterium tuberculosis:4.6 μM(MIC50), Macrophages and pneumocytes:2.3-4.6 μM(MIC50), CYP2C19:0.93μM, CYP3A4:1.2μM |
| In vitro | α-Viniferin at 3 - 10 muM dose-dependently inhibited IFN-gamma-induced production of NO, IFN-gamma-inducible protein-10 (IP-10), or the monokine induced by IFN-gamma (MIG) in RAW 264.7 cells and also that of NO in primary macrophages-derived from C57BL/6 mice. Furthermore, α-Viniferin diminished IFN-gamma-induced protein levels of inducible NO synthase (iNOS), attenuated mRNA levels of iNOS, IP-10, or MIG as well as inhibited promoter activity of the iNOS gene[1].α-viniferin is a bioactive phytochemical compound obtained from Carex humilis, which has the antitubercular activity. α-Viniferin was active against both drug-susceptible and -resistant strains of Mycobacterium tuberculosis at MIC50s of 4.6 μM in culture broth medium and MIC50s of 2.3-4.6 μM inside macrophages and pneumocytes[2]. α-Viniferin strongly inhibited 7 of the 9 P450 (CYP) isoforms (except CYP2A6 and CYP2E1) in human. α-viniferin strongly inhibited CYP2C19-mediated omeprazole 5-hydroxylation and CYP3A4-catalyzed midazolam 1-hydroxylation with IC50 values of 0.93 and 1.2 μM, respectively[3]. |
| In vivo | Oral bioavailability of α-viniferin in mice was 4.2 %.[4] |
| Synonyms | ALPHA-VINIFERIN |
| Molecular Weight | 678.68 |
| Formula | C42H30O9 |
| Cas No. | 62218-13-7 |
| Smiles | OC(C=C1)=CC=C1[C@@H](O2)[C@@H](C3=CC(O)=CC4=C3[C@@H](C5=CC(O)=CC(O6)=C75)[C@H](C8=CC=C(O)C=C8)O4)C9=C2C=C(O)C=C9[C@H]7[C@@H]6C%10=CC=C(O)C=C%10 |
| Relative Density. | 1.517 g/cm3 (Predicted) |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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