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Petosemtamab

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Catalog No. T76890Cas No. 2213450-26-9
Alias MCLA 158

Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab can be used in the study of solid tumors such as head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer (CRC).

Petosemtamab

Petosemtamab

😃Good
Catalog No. T76890Alias MCLA 158Cas No. 2213450-26-9
Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab can be used in the study of solid tumors such as head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer (CRC).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$355In StockIn Stock
5 mg$928In StockIn Stock
10 mg$1,490BackorderBackorder
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:> 95%
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COA SDS-PAGE SEC-HPLC Instruction Manual of Inhibitory Antibody

Product Introduction

Bioactivity
Description
Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab can be used in the study of solid tumors such as head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer (CRC).
Targets&IC50
EGFR:0.22 nM (Kd), LGR5:0.85 nM (Kd)
In vitro
Treatment with MCLA-158(Petosemtamab) (1 µg/mL; 24 or 72 hours) induces the degradation of EGFR in EGFR+/LGR5+ colorectal cancer organoids[2].
In vivo
Treatment with MCLA-158(Petosemtamab) (25 mg/kg/week, intravenous injection, for 6 weeks) leads to tumor regression in esophageal squamous cell carcinoma, gastric adenocarcinoma, and head and neck PDX models[2].
SynonymsMCLA 158
Chemical Properties
Molecular Weight145.97 kDa
Cas No.2213450-26-9
ColorTransparent
AppearanceLiquid
Storage & Solubility Information
Storagestore at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

PetosemtamabMCLA-158MCLA158EGFR
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