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Anti-Phospho-ER alpha (S118) Antibody (5S971)

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Catalog No. TMAC-03214

Anti-Phospho-ER alpha (S118) Antibody (5S971) is a Rabbit antibody targeting Phospho-ER alpha (S118). Anti-Phospho-ER alpha (S118) Antibody (5S971) can be used in WB,ICC/IF,IHC.

Anti-Phospho-ER alpha (S118) Antibody (5S971)

Anti-Phospho-ER alpha (S118) Antibody (5S971)

😃Good
Catalog No. TMAC-03214
Anti-Phospho-ER alpha (S118) Antibody (5S971) is a Rabbit antibody targeting Phospho-ER alpha (S118). Anti-Phospho-ER alpha (S118) Antibody (5S971) can be used in WB,ICC/IF,IHC.
Pack SizePriceAvailabilityQuantity
50 μL$2967-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-ER alpha (S118) Antibody (5S971) is a Rabbit antibody targeting Phospho-ER alpha (S118). Anti-Phospho-ER alpha (S118) Antibody (5S971) can be used in WB,ICC/IF,IHC.
Ig Type
IgG
Reactivity
Human
Application
Recommended Dose
WB: 1:1000; IHC: 1:50-200; ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionHybridoma Monoclonal Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundEstrogen receptor alpha (ERa, ER, ESR, ESRA, Era, NR3A1, estrogen receptor 1) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding and activation of transcription. Alternative splicing results in several ERa mRNA transcripts, which differ primarily in their 5' untranslated regions. ERa undergoes phosphorylation in response to estradiol binding. Human ERa is predominately phosphorylated on Ser 118 and to a lesser extent on Ser 104 and Ser 106. In response to activation of the mitogen-activated protein kinase pathway, phosphorylation occurs on Ser 118 and Ser 167. These serine residues are all located within the activation function 1 region of the N-terminal domain of ERa. In contrast, activation of protein kinase A increases the phosphorylation of Ser 236, which is located in the DNA-binding domain. Src kinase-dependent Tyr 537 phosphorylation may enhance estrogen binding to ERa. Mutation of Tyr 537 of the human ERa produces receptors having a range of constitutive activity.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
A synthesized phosphopeptide: human Estrogen Receptor alpha around the phosphorylation site of Ser118
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 66 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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