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C004019

Name: C004019
Brand: TargetMol
SKU: T67834
Price: 263 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67834 Copy Product Info

Purity: 99.89%

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C004019 belongs to PROTACs and is a tau protein-targeted degrader (via recruitment of VHL E3 ligase) with blood-brain barrier permeability and selective tau degradation capability. This compound significantly reduces tau levels and improves cognitive function, and is used in research on Alzheimer's disease and related tauopathies.

Cas No. 2417159-57-8

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Pack Size	Price	USA Stock	Global Stock
1 mg	$263	In Stock	In Stock
5 mg	$645	In Stock	In Stock
10 mg	$943	In Stock	In Stock
25 mg	$1,380	In Stock	In Stock
50 mg	$1,880	In Stock	In Stock
100 mg	$2,530	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.89%

ee:100%

Appearance:Solid

Color:White

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COA ORP CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	C004019 belongs to PROTACs and is a tau protein-targeted degrader (via recruitment of VHL E3 ligase) with blood-brain barrier permeability and selective tau degradation capability. This compound significantly reduces tau levels and improves cognitive function, and is used in research on Alzheimer's disease and related tauopathies.
Targets & IC50	HEK293-hTau cells:0.00785 μM
In vitro	Methods: HEK293 cells stably expressing full-length human tau protein (HEK293-hTau) and SH-SY5Y cells were treated with C004019 for 24 h, and cell viability and tau protein expression levels were detected, respectively. Results: Within the concentration range of 0.01–100 μM, C004019 had no significant effect on HEK293-hTau cell viability; at concentrations of 0.01–20 μM, C004019 inhibited total tau and phosphorylated tau protein expression.[1]
In vivo	Methods: To evaluate the clearance of brain tau protein and effects on cognitive function by C004019, different administration Methods were employed in wild-type, 3xTg-AD, and hTau mouse models: single intracerebroventricular injection of C004019 (5 μL, 200 μM); single subcutaneous injection (3-15 mg/kg); and long-term subcutaneous injection (3 mg/kg, once every 6 days for a total of 5 times), with detection of brain tau protein levels, cognitive function, and synaptic function changes. Results: Intracerebroventricular administration of C004019 reduced brain tau protein levels in wild-type and 3xTg-AD mice; single subcutaneous injection effectively cleared brain tau protein in wild-type mice; long-term subcutaneous injection promoted brain tau protein clearance in hTau and 3xTg-AD mice and improved their cognitive and synaptic function.[1]

Chemical Properties

Molecular Weight	1035.29
Formula	C₄₉H₇₀N₁₂O₉S₂
Cas No.	2417159-57-8
Smiles	N(CC(NCCOCCOCCOCC(N[C@H](C(=O)N1[C@@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](O)C1)C(C)(C)C)=O)=O)(C)C4=NC(=NC(NCCC5=CC=CS5)=N4)N6CCN(C(C)=O)CCC6
Relative Density.	1.300 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255 mg/mL (246.31 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9659 mL	4.8296 mL	9.6591 mL	48.2956 mL
5 mM	0.1932 mL	0.9659 mL	1.9318 mL	9.6591 mL
10 mM	0.0966 mL	0.4830 mL	0.9659 mL	4.8296 mL
20 mM	0.0483 mL	0.2415 mL	0.4830 mL	2.4148 mL
50 mM	0.0193 mL	0.0966 mL	0.1932 mL	0.9659 mL
100 mM	0.0097 mL	0.0483 mL	0.0966 mL	0.4830 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc