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C004019

Name: C004019
Brand: TargetMol
SKU: T67834
Price: 263 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67834Cas No. 2417159-57-8

C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases.

C004019

🥰Excellent

Purity: 99.89%

Catalog No. T67834Cas No. 2417159-57-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$263	In Stock	In Stock
5 mg	$645	In Stock	In Stock
10 mg	$943	In Stock	In Stock
25 mg	$1,380	In Stock	In Stock
50 mg	$1,880	In Stock	In Stock
100 mg	$2,530	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.89%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA LCMS CSFC HNMR ORP

Product Introduction

Bioactivity

Description	C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases.
Targets&IC50	HEK293-hTau cells:0.00785 μM
In vitro	C004019 induced a robust tau clearance via promoting its ubiquitination-proteasome-dependent proteolysis in HEK293 cells with stable or transient overexpression of human tau (hTau), and in SH-SY5Y that constitutively overexpress hTau.[1]
In vivo	C004019 induced a robust tau clearance in vivo by intracerebral ventricular infusion. Most importantly, both single-dose and multiple-doses (once per 6 days for a total of 5 times) subcutaneous administration of C004019 remarkably decreased tau levels in the brains of wild-type, hTau-transgenic and 3xTg-AD mice with the improvement of synaptic and cognitive functions.[1]

Chemical Properties

Molecular Weight	1035.29
Formula	C₄₉H₇₀N₁₂O₉S₂
Cas No.	2417159-57-8
Smiles	N(CC(NCCOCCOCCOCC(N[C@H](C(=O)N1[C@@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](O)C1)C(C)(C)C)=O)=O)(C)C4=NC(=NC(NCCC5=CC=CS5)=N4)N6CCN(C(C)=O)CCC6
Relative Density.	1.300 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255 mg/mL (246.31 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9659 mL	4.8296 mL	9.6591 mL	48.2956 mL
5 mM	0.1932 mL	0.9659 mL	1.9318 mL	9.6591 mL
10 mM	0.0966 mL	0.4830 mL	0.9659 mL	4.8296 mL
20 mM	0.0483 mL	0.2415 mL	0.4830 mL	2.4148 mL
50 mM	0.0193 mL	0.0966 mL	0.1932 mL	0.9659 mL
100 mM	0.0097 mL	0.0483 mL	0.0966 mL	0.4830 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc