S65487 hydrochloride

Name: S65487 hydrochloride
Brand: TargetMol
SKU: T39135
Rating: 4.5 (1 reviews)

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Catalog No. T39135Cas No. 1644543-95-2

Alias VOB560 hydrochloride, S65487 hydrochloride

S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y, while exhibiting poor affinity for MCL-1, BFL-1, and BCL-XL. This compound induces apoptosis and possesses anticancer activities.

S65487 hydrochloride

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Catalog No. T39135Alias VOB560 hydrochloride, S65487 hydrochlorideCas No. 1644543-95-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$697	Inquiry	Inquiry
25 mg	$1,490	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y, while exhibiting poor affinity for MCL-1, BFL-1, and BCL-XL. This compound induces apoptosis and possesses anticancer activities.
In vitro	S65487 hydrochloride engages with the BH3 hydrophobic groove of BCL-2, effectively inducing apoptosis in various hematological cancer cell lines while concurrently inhibiting cell proliferation. Its inhibitory concentration 50 (IC50s) values are in the low nanomolar (nM) range[1].
In vivo	S65487 hydrochloride effectively induces complete regression of BCL-2-dependent RS4;11 tumors in vivo with just one intravenous (IV) administration. When administered weekly via IV at doses well tolerated by the organism, a combination of S65487 hydrochloride and the MCL-1-specific inhibitor, S64315/MIK665, results in strong and persistent regression of lymphoid malignancy xenograft models in both mice and rats[1].
Synonyms	VOB560 hydrochloride, S65487 hydrochloride

Chemical Properties

Molecular Weight	753.73
Formula	C₄₁H₄₂Cl₂N₆O₄
Cas No.	1644543-95-2
Smiles	Cl.Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc