Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y. It exhibits poor affinity for MCL-1, BFL-1, and BCL-XL. This compound induces apoptosis and possesses anticancer activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | Inquiry | $ 697.00 | |
25 mg | Inquiry | $ 1,490.00 |
Description | S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y. It exhibits poor affinity for MCL-1, BFL-1, and BCL-XL. This compound induces apoptosis and possesses anticancer activities. |
In vitro | S65487 hydrochloride engages with the BH3 hydrophobic groove of BCL-2, effectively inducing apoptosis in various hematological cancer cell lines while concurrently inhibiting cell proliferation. Its inhibitory concentration 50 (IC50s) values are in the low nanomolar (nM) range[1]. |
In vivo | S65487 hydrochloride effectively induces complete regression of BCL-2-dependent RS4;11 tumors in vivo with just one intravenous (IV) administration. When administered weekly via IV at doses well tolerated by the organism, a combination of S65487 hydrochloride and the MCL-1-specific inhibitor, S64315/MIK665, results in strong and persistent regression of lymphoid malignancy xenograft models in both mice and rats[1]. |
Synonyms | S65487 hydrochloride, VOB560 hydrochloride |
Molecular Weight | 753.73 |
Formula | C41H42Cl2N6O4 |
CAS No. | 1644543-95-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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S65487 hydrochloride 1644543-95-2 S 65487 Hydrochloride S-65487 Hydrochloride S-65487 hydrochloride VOB 560 Hydrochloride VOB560 hydrochloride VOB560 Hydrochloride VOB-560 Hydrochloride S65487 Hydrochloride inhibitor inhibit