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Quinizarin
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Catalog No. TN2132Cas No. 81-64-1
Alias 1,4-Dihydroxyanthraquinone
Quinizarin (1,4-Dihydroxyanthraquinone) is a natural product
Quinizarin
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Purity: 95.02%
Catalog No. TN2132Alias 1,4-DihydroxyanthraquinoneCas No. 81-64-1
Quinizarin (1,4-Dihydroxyanthraquinone) is a natural product
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 g | $29 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95.02%
Appearance:Solid
Color:Red
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Product Introduction
Quinizarin AI Summary
Quinizarin exhibits diverse bioactivities across multiple biological systems. It has shown inhibitory activity against various cancer cell lines, including B16 murine melanoma, HCT 116 human colon cancer, and A 431 human epidermoid carcinoma, with an IC50 concentration greater than 30.0 µg/mL. Additionally, it enhances the proliferation of the MCF-7 cell line at low micromolar concentrations and exhibits significant cytotoxicity against CaSki cells. It demonstrates antifilarial activity against Brugia malayi with a 10.0% mortality rate at 5 ppm within the first 5 days.
In microbiological contexts, Quinizarin inhibits planktonic Streptococcus mutans with an MIC of 250.0 µg/mL and effectively reduces biofilm formation at 5 µg/mL, achieving an 80.0% inhibition rate. It also exhibits notable antiplatelet activity in rat platelet-rich plasma, inhibiting aggregation at concentrations over 0.25 mg/ml. Furthermore, it displays substantial in vitro bioactivities, including the inhibition of CK1 isoforms, enhancement of human kidney stone and calcium oxalate dissolution, and activity in various enzyme assays such as UGT1A1 and UGT1A9.
Quinizarin inhibited Menin-MLL interaction, tau fibril formation, and Bacillus subtilis Sfp phosphopantetheinyl transferase with significant potencies and displayed regulation of epigenetic processes. It did not significantly inhibit topoisomerase 2 or show cytotoxicity in various human cell lines like HeLa and HepG2.
This compound also selectively inhibited recombinant human MAO-A, with an IC50 of 65.0 nM and a Ki of 39.0 nM, and showed lower activity against MAO-B, demonstrating a high selectivity index. It binds to calf thymus DNA through partial intercalation and hydrogen bonding, and has limited activity against rat liver cytosolic TrxR1 and mitochondrial TrxR2. Overall, Quinizarin exhibits multifaceted bioactivity, making it a compound of interest for further pharmacological studies..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Quinizarin (1,4-Dihydroxyanthraquinone) is a natural product |
| Synonyms | 1,4-Dihydroxyanthraquinone |
| Molecular Weight | 240.21 |
| Formula | C14H8O4 |
| Cas No. | 81-64-1 |
| Smiles | Oc1ccc(O)c2C(=O)c3ccccc3C(=O)c12 |
| Relative Density. | 1.3032 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.55 mg/mL (14.78 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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