HER2/ERBB2 Protein, Human, Recombinant (mFc)

Catalog No. TMPY-06612

HER2/ERBB2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 95.75 kDa and the accession number is NP_004439.2.

HER2/ERBB2 Protein, Human, Recombinant (mFc)

Catalog No. TMPY-06612

HER2/ERBB2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 95.75 kDa and the accession number is NP_004439.2.

Pack Size	Price	Availability	Quantity
100 μg	$600	7-10 days
1 mg	$3,910	7-10 days

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Product Information

Biological Activity	Immobilized Recombinant Human Her2/ERBB2 Protein (ECD, mFc Tag) at 2 μg/ml (100 μl/well) can bind Anti-Erbb2 Antibody (Trastuzumab), the EC50 is 12-36 ng/mL.
Description	HER2/ERBB2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 95.75 kDa and the accession number is NP_004439.2.
Species	Human
Expression System	HEK293 Cells
Tag	C-mFc
Accession Number	NP_004439.2
Synonyms	TKR1,NGL,NEU,MLN19,MLN 19,HERV-W-ENV,HERVWENV,HERVW,HERV-7q,HERV7Q,HER-2/neu,HER-2,HER2,ERVWE1,erb-b2 receptor tyrosine kinase 2,ENVW,ENV,EGFR2,CD340
Construction	A DNA sequence encoding the human Her2/ERBB2 (NP_004439.2) (Met1-Thr652) was expressed with the Fc region of mouse IgG1 at the C-terminus. Predicted N terminal: Thr 23
Protein Purity	> 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-HPLC.
Molecular Weight	95.75 kDa (predicted); 120.60 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy