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Pramlintide acetate(151126-32-8 free base)

Name: Pramlintide acetate(151126-32-8 free base)
Brand: TargetMol
SKU: TP2320
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Pramlintide acetate, a polypeptide analogue of human amylin, functions as an antidiabetic agent and exhibits antineoplastic activity in colorectal cancer.

Pramlintide acetate(151126-32-8 free base)

Cas No. 187887-46-3

Pack Size	Price	USA Stock	Global Stock
1 mg	$36	In Stock	In Stock
5 mg	$88	In Stock	In Stock
10 mg	$137	In Stock	In Stock
25 mg	$298	In Stock	In Stock
50 mg	$433	In Stock	In Stock
100 mg	$592	In Stock	In Stock
200 mg	$783	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Pramlintide acetate, a polypeptide analogue of human amylin, functions as an antidiabetic agent and exhibits antineoplastic activity in colorectal cancer.
In vitro	Pramlintide inhibited the growth of HCT-116 and HT-29 in a dose-dependent manner, with higher efficacy against the latter (IC50s; 48.67 and 9.10 μg/mL, respectively;?p-value =0.013). Moreover, the addition of 5, 10, and 20 μg/mL of pramlintide to HCT-116 and HT-29 with 5-fluorouracil, oxaliplatin, or irinotecan induced the antiproliferative effect synergistically (R>1.6,?p-value <0.05).

Chemical Properties

Molecular Weight	4009
Formula	C₁₇₃H₂₇₁N₅₁O₅₅S₂
Cas No.	187887-46-3
Smiles	CC[C@@H]([C@H](NC([C@@H]1CCCN1C(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]2CSSC[C@H](NC([C@@H](N)CCCCN)=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N2)=O)=O)=O)=O)=O)=O)C)=O)[C@H](O)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)C)=O)CC(N)=O)=O)CC3=CC=CC=C3)=O)CC(C)C)=O)C(C)C)=O)CC4=CNC=N4)=O)CO)=O)CO)=O)CC(N)=O)=O)CC(N)=O)=O)CC5=CC=CC=C5)=O)=O)=O)C(N[C@H](C(N6CCC[C@H]6C(N7CCC[C@H]7C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC8=CC=C(O)C=C8)=O)[C@H](O)C)=O)CC(N)=O)=O)CO)=O)=O)C(C)C)=O)CC(N)=O)=O)[C@H](O)C)=O)=O)=O)CC(C)C)=O)C.CC(O)=O
Relative Density.	no data available
Sequence	Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-NH₂ (Disulfide bridge:Cys2-Cys7)
Sequence Short	KCNTATCATQRLANFLVHSS

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mM

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.2494 mL	1.2472 mL	2.4944 mL	12.4719 mL
5 mM	0.0499 mL	0.2494 mL	0.4989 mL	2.4944 mL
10 mM	0.0249 mL	0.1247 mL	0.2494 mL	1.2472 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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Related Tags: Pramlintide acetate(151126-32-8 free base) chemical structure | Pramlintide acetate(151126-32-8 free base) in vitro | Pramlintide acetate(151126-32-8 free base) formula | Pramlintide acetate(151126-32-8 free base) molecular weight