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Anti-ACCN1 Polyclonal Antibody
(Synonyms: Neuronal amiloride sensitive cation channel 1, MDEG, Mammalian degenerin homolog, hBNaC1, Degenerin, Brain sodium channel 1, BNaC1, ASICs2 ACCN1_HUMAN, ASIC2a, ASIC2, Amiloride-sensitive cation channel neuronal 1, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive brain sodium channel, Amiloride sensitive cation channel 1 neuronal(degenerin), Amiloride sensitive cation channel 1 neuronal, Amiloride sensitive brain sodium channel, Acid-sensing ion channel 2, Acid sensing ion channel 2, ACCN) Copy Product Info
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Synonyms: Neuronal amiloride sensitive cation channel 1, MDEG, Mammalian degenerin homolog, hBNaC1, Degenerin, Brain sodium channel 1, BNaC1, ASICs2 ACCN1_HUMAN, ASIC2a, ASIC2, Amiloride-sensitive cation channel neuronal 1, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive brain sodium channel, Amiloride sensitive cation channel 1 neuronal(degenerin), Amiloride sensitive cation channel 1 neuronal, Amiloride sensitive brain sodium channel, Acid-sensing ion channel 2, Acid sensing ion channel 2, ACCN
Catalog No. TMAB-02192 Copy Product Info
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Anti-ACCN1 Polyclonal Antibody is a Rabbit antibody targeting ACCN1. Anti-ACCN1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-ACCN1 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-ACCN1 Polyclonal Antibody is a Rabbit antibody targeting ACCN1. Anti-ACCN1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Synonyms | Neuronal amiloride sensitive cation channel 1, MDEG, Mammalian degenerin homolog, hBNaC1, Degenerin, Brain sodium channel 1, BNaC1, ASICs2 ACCN1_HUMAN, ASIC2a, ASIC2, Amiloride-sensitive cation channel neuronal 1, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive brain sodium channel, Amiloride sensitive cation channel 1 neuronal(degenerin), Amiloride sensitive cation channel 1 neuronal, Amiloride sensitive brain sodium channel, Acid-sensing ion channel 2, Acid sensing ion channel 2, ACCN |
| Ig Type | IgG |
| Reactivity | Human,Rat (predicted:Mouse,Dog,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane. Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. |
| Tissue Specificity | Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Degenerin/epithelial sodium channel (DEG/ENaC) superfamily members are amiloride-sensitive sodium channels that contain intracellular N- and C-termini, 2 two hydrophobic transmembrane regions and a cysteine-containing extracellular loop. Acid sensing ion channel ASIC1, also designated ACCN2, BNAC2 and ASIC1a, is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety. ASIC2, also designated amiloride-sensitive cation channel 1, neuronal (ACCN1), mammalian degenerin, BNAC1 (MDEG) and brain Na+ channel 1, mediates the normal detection of light touch. ASIC2 mRNA is abundant in brain, specifically in neurons. ASIC2 is expressed as 2.7- and 3.7-kb transcripts in brain and spinal cord tissues. ASIC3, also designated ASIC3, SLNAC1 and TNaC1, mediates detection of lasting pH changes and is involved in modulating moderate- to high-intensity pain sensation. ASIC4, also designated ACCN4 and BNAC4, is abundant in pituitary gland and is also present in the inner ear. |
| Immunogen | KLH conjugated synthetic peptide: human ACCN1 |
| Antigen Species | Human |
| Gene Name | ASIC2 |
| Gene ID | |
| Protein Name | Acid-sensing ion channel 2 |
| Uniprot ID | |
| Function | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. |
| Molecular Weight | Theoretical: 56 kDa. Actual: 60,63 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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