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Anti-ACCN1 Polyclonal Antibody
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Catalog No. TMAB-02192
Alias Neuronal amiloride sensitive cation channel 1, MDEG, Mammalian degenerin homolog, hBNaC1, Degenerin, Brain sodium channel 1, BNaC1, ASICs2 ACCN1_HUMAN, ASIC2a, ASIC2, Amiloride-sensitive cation channel neuronal 1, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive brain sodium channel, Amiloride sensitive cation channel 1 neuronal(degenerin), Amiloride sensitive cation channel 1 neuronal, Amiloride sensitive brain sodium channel, Acid-sensing ion channel 2, Acid sensing ion channel 2, ACCN
Anti-ACCN1 Polyclonal Antibody is a Rabbit antibody targeting ACCN1. Anti-ACCN1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-ACCN1 Polyclonal Antibody
Anti-ACCN1 Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-02192Alias Neuronal amiloride sensitive cation channel 1, MDEG, Mammalian degenerin homolog, hBNaC1, Degenerin, Brain sodium channel 1, BNaC1, ASICs2 ACCN1_HUMAN, ASIC2a, ASIC2, Amiloride-sensitive cation channel neuronal 1, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive brain sodium channel, Amiloride sensitive cation channel 1 neuronal(degenerin), Amiloride sensitive cation channel 1 neuronal, Amiloride sensitive brain sodium channel, Acid-sensing ion channel 2, Acid sensing ion channel 2, ACCN
Anti-ACCN1 Polyclonal Antibody is a Rabbit antibody targeting ACCN1. Anti-ACCN1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Antigen Details
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| Description | Anti-ACCN1 Polyclonal Antibody is a Rabbit antibody targeting ACCN1. Anti-ACCN1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Synonyms | Neuronal amiloride sensitive cation channel 1, MDEG, Mammalian degenerin homolog, hBNaC1, Degenerin, Brain sodium channel 1, BNaC1, ASICs2 ACCN1_HUMAN, ASIC2a, ASIC2, Amiloride-sensitive cation channel neuronal 1, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive brain sodium channel, Amiloride sensitive cation channel 1 neuronal(degenerin), Amiloride sensitive cation channel 1 neuronal, Amiloride sensitive brain sodium channel, Acid-sensing ion channel 2, Acid sensing ion channel 2, ACCN |
| Ig Type | IgG |
| Reactivity | Human,Rat (predicted:Mouse,Dog,Cow,Horse,Rabbit) |
| Verified Activity | 1. Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01 M, pH 6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37℃ for 20 min; Incubation: Anti-ACCN1 Polyclonal Antibody, Unconjugated (TMAB-02192) 1: 200, overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining 2. Sample: Lane 1: Human SH-SY5Y cell lysates Lane 2: Human U251 cell lysates Lane 3: Human U-2 OS cell lysates Lane 4: Human Jurkat cell lysates Primary: Anti-ACCN1 (TMAB-02192) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56 kDa Observed band size: 60,63 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane. Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. |
| Tissue Specificity | Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Degenerin/epithelial sodium channel (DEG/ENaC) superfamily members are amiloride-sensitive sodium channels that contain intracellular N- and C-termini, 2 two hydrophobic transmembrane regions and a cysteine-containing extracellular loop. Acid sensing ion channel ASIC1, also designated ACCN2, BNAC2 and ASIC1a, is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety. ASIC2, also designated amiloride-sensitive cation channel 1, neuronal (ACCN1), mammalian degenerin, BNAC1 (MDEG) and brain Na+ channel 1, mediates the normal detection of light touch. ASIC2 mRNA is abundant in brain, specifically in neurons. ASIC2 is expressed as 2.7- and 3.7-kb transcripts in brain and spinal cord tissues. ASIC3, also designated ASIC3, SLNAC1 and TNaC1, mediates detection of lasting pH changes and is involved in modulating moderate- to high-intensity pain sensation. ASIC4, also designated ACCN4 and BNAC4, is abundant in pituitary gland and is also present in the inner ear. |
| Immunogen | KLH conjugated synthetic peptide: human ACCN1 |
| Antigen Species | Human |
| Gene Name | ASIC2 |
| Gene ID | |
| Protein Name | Acid-sensing ion channel 2 |
| Uniprot ID | |
| Function | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. |
| Molecular Weight | Theoretical: 56 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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