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SIRP alpha V6 Protein, Human, Recombinant (His & Avi)

Catalog No. TMPK-01358
Synonyms: P84, SIRPA, SIRP alpha, SHPS-1, MFR, BIT, MYD1, SIRP α V6, SHPS1, SIRP α, CD172a, PTPNS1, MYD-1

Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 39.9 kDa and the accession number is P78324 variant 6.

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SIRP alpha V6 Protein, Human, Recombinant (His & Avi)
Pack Size Availability Price/USD Quantity
100 μg 5 days $ 487.00
500 μg 5 days $ 1,950.00
1 mg 5 days $ 3,250.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 39.9 kDa and the accession number is P78324 variant 6.
Species Human
Expression System HEK293 Cells
Tag C-His-Avi
Accession Number P78324 variant 6
Synonyms P84, SIRPA, SIRP alpha, SHPS-1, MFR, BIT, MYD1, SIRP α V6, SHPS1, SIRP α, CD172a, PTPNS1, MYD-1
Construction Glu31-Arg370(S105P)
Protein Purity > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight 39.9 kDa (predicted). Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
Endotoxin < 1 EU/μg by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
Reconstitution Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction.

References and Literature

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Keywords

SIRP alpha V6 Protein, Human, Recombinant (His & Avi) P84 P 84 SIRPA SIRP alpha SHPS-1 SHPS 1 PTPNS 1 MFR BIT P-84 MYD1 SIRP α V6 SHPS1 MYD 1 SIRP α CD172a PTPNS1 PTPNS-1 MYD-1 recombinant recombinant-proteins proteins protein

 

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