Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. AGR3 was found in breast, ovary, prostate, and liver cancer, it is associated with the level of differentiation, slowly proliferating tumors, and more favorable prognosis of breast cancer patients. AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway. AGR3 had been characterised as a novel potential biomarker both for breast cancer prognosis and early breast cancer detection from blood.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 5 days | $ 498.00 |
Description | Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. AGR3 was found in breast, ovary, prostate, and liver cancer, it is associated with the level of differentiation, slowly proliferating tumors, and more favorable prognosis of breast cancer patients. AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway. AGR3 had been characterised as a novel potential biomarker both for breast cancer prognosis and early breast cancer detection from blood. |
Species | Human |
Expression System | HEK293 |
Tag | mFc |
Accession Number | Q8TD06 |
Synonyms | hAG-3, AG3, HAG3, anterior gradient 3, PDIA18, BCMP11, AG-3 |
Construction | A DNA sequence encoding the human AGR3 (NP_789783.1) (Met1-Leu166) was expressed with the Fc region of mouse IgG1 at the C-terminus. |
Protein Purity | > 85 % as determined by SDS-PAGE. |
Molecular Weight | 43.4 kDa (predicted) |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
Reconstitution | A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information. |
Stability & Storage |
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. AGR3 was found in breast, ovary, prostate, and liver cancer, it is associated with the level of differentiation, slowly proliferating tumors, and more favorable prognosis of breast cancer patients. AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway. AGR3 had been characterised as a novel potential biomarker both for breast cancer prognosis and early breast cancer detection from blood. |
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Please read the User Guide of Recombinant Proteins for more specific information.
AGR3 Protein, Human, Recombinant (mFc) hAG-3 AG3 AG 3 HAG3 PDIA 18 HAG 3 anterior gradient 3 PDIA18 HAG-3 BCMP11 BCMP-11 PDIA-18 BCMP 11 AG-3 recombinant recombinant-proteins proteins protein