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Edg-2 receptor inhibitor 1

Name: Edg-2 receptor inhibitor 1
Brand: TargetMol
SKU: T4521
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4521Cas No. 1195941-38-8

Alias SAR-100842

Edg-2 receptor inhibitor 1 (SAR-100842) is an Edg-2 receptor inhibitor extracted (IC50: <0.1 μM).

Edg-2 receptor inhibitor 1

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Purity: 99.47%

Catalog No. T4521Alias SAR-100842Cas No. 1195941-38-8

Edg-2 receptor inhibitor 1 (SAR-100842) is an Edg-2 receptor inhibitor extracted (IC50: <0.1 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	In Stock	In Stock
2 mg	$178	In Stock	In Stock
5 mg	$288	In Stock	In Stock
10 mg	$449	In Stock	In Stock
25 mg	$698	In Stock	In Stock
50 mg	$996	In Stock	In Stock
100 mg	$1,330	-	In Stock
1 mL x 10 mM (in DMSO)	$303	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.47%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Edg-2 receptor inhibitor 1 (SAR-100842) is an Edg-2 receptor inhibitor extracted (IC50: <0.1 μM).
Targets&IC50	Edg2 receptor:<0.1 μM
In vitro	Edg-2 receptor inhibitor 1 is an inhibitor of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and is useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example[1].
Synonyms	SAR-100842

Chemical Properties

Molecular Weight	445.51
Formula	C₂₇H₂₇NO₅
Cas No.	1195941-38-8
Smiles	N(C(=O)C1=CC(OCCC2=CC(C)=CC=C2)=C(OC)C=C1)C3(C(O)=O)CC=4C(C3)=CC=CC4
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 41.67 mg/mL (93.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2446 mL	11.2231 mL	22.4462 mL	112.2309 mL
5 mM	0.4489 mL	2.2446 mL	4.4892 mL	22.4462 mL
10 mM	0.2245 mL	1.1223 mL	2.2446 mL	11.2231 mL
20 mM	0.1122 mL	0.5612 mL	1.1223 mL	5.6115 mL
50 mM	0.0449 mL	0.2245 mL	0.4489 mL	2.2446 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc