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[Leu5]-Enkephalin, amide acetate

🥰Excellent
Catalog No. TP1113L
Alias [Leu5]-Enkephalin, amide acetate(60117-24-0 free base)

[Leu5]-Enkephalin, amide acetate is a δ opioid receptor agonist.

[Leu5]-Enkephalin, amide acetate

[Leu5]-Enkephalin, amide acetate

🥰Excellent
Purity: 99.36%
Catalog No. TP1113LAlias [Leu5]-Enkephalin, amide acetate(60117-24-0 free base)
[Leu5]-Enkephalin, amide acetate is a δ opioid receptor agonist.
Pack SizePriceAvailabilityQuantity
2 mg$32In Stock
5 mg$47In Stock
10 mg$67In Stock
25 mg$126In Stock
50 mg$189In Stock
100 mg$285In Stock
200 mg$427In Stock
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Purity:99.36%
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Product Introduction

Bioactivity
Description
[Leu5]-Enkephalin, amide acetate is a δ opioid receptor agonist.
In vitro
[Leu5]-Enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 of 2.1 nM.[1]
In vivo
Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05)[2].
Synonyms[Leu5]-Enkephalin, amide acetate(60117-24-0 free base)
Chemical Properties
Molecular Weight614.69
FormulaC30H42N6O8
SmilesCC(O)=O.O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N
Relative Density.no data available
ColorWhite
AppearanceSolid
SequenceH-Tyr-Gly-Gly-Phe-Leu-OH
Sequence ShortYGGFL
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

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