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[Leu5]-Enkephalin, amide acetate

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Catalog No. TP1113L
Alias [Leu5]-Enkephalin, amide acetate(60117-24-0 free base)

[Leu5]-Enkephalin, amide acetate is a δ opioid receptor agonist.

[Leu5]-Enkephalin, amide acetate

[Leu5]-Enkephalin, amide acetate

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Purity: 99.36%
Catalog No. TP1113LAlias [Leu5]-Enkephalin, amide acetate(60117-24-0 free base)
[Leu5]-Enkephalin, amide acetate is a δ opioid receptor agonist.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$32In StockIn Stock
5 mg$47In StockIn Stock
10 mg$67In StockIn Stock
25 mg$126In StockIn Stock
50 mg$189In StockIn Stock
100 mg$285In StockIn Stock
200 mg$427In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.36%
Appearance:Solid
Color:White
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COA MS HPLC

Product Introduction

Bioactivity
Description
[Leu5]-Enkephalin, amide acetate is a δ opioid receptor agonist.
In vitro
[Leu5]-Enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 of 2.1 nM.[1]
In vivo
Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05)[2].
Synonyms[Leu5]-Enkephalin, amide acetate(60117-24-0 free base)
Chemical Properties
Molecular Weight614.69
FormulaC30H42N6O8
SmilesCC(O)=O.O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N
Relative Density.no data available
SequenceH-Tyr-Gly-Gly-Phe-Leu-OH
Sequence ShortYGGFL
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

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