EGFR Protein, Mouse, Recombinant (hFc)

Name: EGFR Protein, Mouse, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-02675
Rating: 4.5 (1 reviews)

(Synonyms: Wa5, wa-2, wa2, Errp, Errb1, Erbb, epidermal growth factor receptor, AI552599, 9030024J15Rik) Copy Product Info

Synonyms: Wa5, wa-2, wa2, Errp, Errb1, Erbb, epidermal growth factor receptor, AI552599, 9030024J15Rik

Catalog No. TMPY-02675 Copy Product Info

EGFR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96 kDa and the accession number is Q01279.

Pack Size	Price	USA Stock	Global Stock
5 µg	$68	7-10 days	7-10 days
10 µg	$108	7-10 days	7-10 days
20 µg	$178	7-10 days	7-10 days
50 µg	$359	7-10 days	7-10 days
100 µg	$696	7-10 days	7-10 days
200 µg	$1,060	7-10 days	7-10 days
500 µg	$2,230	7-10 days	7-10 days
1 mg	$4,530	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1.Immobilized Recombinant Mouse EGFR/HER1/ErbB1 Protein (Fc Tag) (Cat#TMPY-02675) at 2 μg/mL (100 μL/well) can bind Recombinant Human EGF/Epidermal Growth Factor Protein (Fc Tag), Biotinylated, the EC50 is 11.3 ng/mL (Routinely tested). 2.Immobilized Recombinant Mouse EGFR/HER1/ErbB1 Protein (Fc Tag) (Cat#TMPY-02675) at 2 μg/mL (100 μL/well) can bind Recombinant Mouse EGF/Epidermal Growth Factor Protein (Fc Tag), Biotinylated, the EC50is 1.5-4.5 ng/mL (QC tested).
Description	EGFR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96 kDa and the accession number is Q01279.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q01279
Construction	A DNA sequence encoding the extracellular domain of mouse EGFR (Q01279) (Met 1-Ser 647) was fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Leu 25
Protein Purity	> 90 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	Wa5, wa-2, wa2, Errp, Errb1, Erbb, epidermal growth factor receptor, AI552599, 9030024J15Rik
Research Background	As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

96 kDa (predicted); 130 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.