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YC-001

Name: YC-001
Brand: TargetMol
SKU: T73476
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: YC001, YC 001) Copy Product Info

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Synonyms: YC001, YC 001

Catalog No. T73476 Copy Product Info

Purity: 99.52%

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YC-001 is an inverse agonist and antagonist targeting rod opsin. YC-001 binds reversibly to rod opsin, thereby stabilizing its structure and protecting mice from bright light-induced retinal degeneration, showing potential for research on retinal degenerative diseases.

Cas No. 748778-73-6

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Pack Size	Price	USA Stock	Global Stock
1 mg	$32	-	In Stock
5 mg	$73	-	In Stock
10 mg	$118	-	In Stock
25 mg	$193	-	In Stock
50 mg	$286	-	In Stock
100 mg	$423	-	In Stock
1 mL x 10 mM (in DMSO)	$80	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.52%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	YC-001 is an inverse agonist and antagonist targeting rod opsin. YC-001 binds reversibly to rod opsin, thereby stabilizing its structure and protecting mice from bright light-induced retinal degeneration, showing potential for research on retinal degenerative diseases.
Targets & IC50	rod opsin:0.98 μM (EC₅₀)
In vitro	Methods: In vitro assays were performed using gradient concentrations of YC-001 (0–100 μM). Results: The potency of YC-001 was 8.7 μM, with an efficacy range of 150–310%. Methods: Samples were treated with gradient concentrations of YC-001 (0.5, 1, 5, 10, 20, 40 μM). Results: YC-001 improved the glycosylation profile of the P23H rhodopsin mutant. Methods: Binding assays were conducted using gradient concentrations of YC-001 (0–1.5 μM). Results: YC-001 bound reversibly to rod opsin, with an EC50 of 0.98 μM. Methods: NIH3T3 cells were treated with gradient concentrations of YC-001 (0.313, 0.625, 1.25, 2.5, 5, 10, 20, 80 μM). Results: YC-001 dose-dependently increased intracellular cAMP levels in NIH3T3 cells.
In vivo	Methods: Abca4⁻/⁻Rdh8⁻/⁻ mice were intraperitoneally injected with YC-001 (50, 200 mg/kg). Results: YC-001 protected Abca4⁻/⁻Rdh8⁻/⁻ mice against bright light–induced retinal degeneration. Methods: Mice were administered YC-001 systemically via intraperitoneal injection (200 mg/kg). Results: YC-001 could penetrate into mouse eyes after systemic administration but could not be retained for a long time. Methods: Mice were intraperitoneally injected with YC-001 (100 mg/kg, 200 mg/kg) once daily for 24 consecutive days. Results: YC-001 showed almost no acute toxicity[1].
Synonyms	YC001, YC 001

Chemical Properties

Molecular Weight	282.77
Formula	C₁₂H₇ClO₂S₂
Cas No.	748778-73-6
Smiles	O=C1OCC(C=2SC(Cl)=CC2)=C1C=3SC=CC3

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (282.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5364 mL	17.6822 mL	35.3644 mL	176.8222 mL
5 mM	0.7073 mL	3.5364 mL	7.0729 mL	35.3644 mL
10 mM	0.3536 mL	1.7682 mL	3.5364 mL	17.6822 mL
20 mM	0.1768 mL	0.8841 mL	1.7682 mL	8.8411 mL
50 mM	0.0707 mL	0.3536 mL	0.7073 mL	3.5364 mL
100 mM	0.0354 mL	0.1768 mL	0.3536 mL	1.7682 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: YC-001 chemical structure | YC-001 in vivo | YC-001 in vitro | YC-001 formula | YC-001 molecular weight