Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the prevention of heart failure.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 148.00 | |
5 mg | In stock | $ 372.00 | |
10 mg | In stock | $ 556.00 | |
25 mg | In stock | $ 896.00 | |
50 mg | In stock | $ 1,220.00 | |
100 mg | In stock | $ 1,650.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 397.00 |
Description | BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the prevention of heart failure. |
Targets&IC50 | FPR2 (human):0.41 nM (EC50), FPR2 (mouse):3.4 nM (EC50), FPR1 (human):2800 nM (EC50) |
In vitro | BMS-986235 inhibits neutrophil chemotaxis and stimulats macrophage phagocytosis, thereby promoting resolution of inflammation[1]. |
In vivo | In male C57BL/6 mice, BMS-986235 (0.3 mg/kg; p.o.) attenuates left ventricle and global cardiac remodeling after left anterior descending and reduces infarct length by 39% relative to the vehicle. BMS-986235 (1 mg/kg; p.o.) shows the Cmax, T1/2, AUC0-inf, and bioavailability (BA) values of 160 nmol/L, 0.68 hours,120 nmol/L•h, and 24%, respectively[1]. |
Synonyms | BMS-986235, LAR-1219 |
Molecular Weight | 361.34 |
Formula | C18H17F2N3O3 |
CAS No. | 2253947-47-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (262.91 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BMS-986235 2253947-47-4 Others Inhibitor macrophage phagocytosis heart BMS 986235 LAR 1219 chemotaxis failure inhibit inflammation neutrophil BMS986235 LAR-1219 LAR1219 inhibitor