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YM-264

Name: YM-264
Brand: TargetMol
SKU: T13369
Rating: 4.5 (1 reviews)

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Catalog No. T13369Cas No. 131888-54-5

YM-264 is a selective and orally active antagonist of platelet-activating factor (PAF) (pKi value of 8.85 for rabbit platelet membranes).

YM-264

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Catalog No. T13369Cas No. 131888-54-5

YM-264 is a selective and orally active antagonist of platelet-activating factor (PAF) (pKi value of 8.85 for rabbit platelet membranes).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	YM-264 is a selective and orally active antagonist of platelet-activating factor (PAF) (pKi value of 8.85 for rabbit platelet membranes).
Targets&IC50	PAF (rabbit platelet membranes):pki： 8.85
In vitro	YM-264 inhibits [3H] platelet-activating factor binding to rabbit platelet membranes with a pKivalue of 8.85. YM-264 inhibits the platelet-activating factor-induced human, rabbit and guinea-pig platelet aggregation with pA2 values of 8.68, 8.33 and 8.14, respectively[1].
In vivo	Antigen exposure-induced airway hyperresponsiveness is significantly reduced with YM-264 administration. The control group shows a baseline airway resistance (Rrs) value of 0.40 (0.02) cm H2O/mL/s (n=6), compared to YM-264 treated groups which exhibit baseline Rrs values of 0.39 (0.01) cm H2O/mL/s for 1 mg/kg (n=5) and 0.36 (0.01) cm H2O/mL/s for 3 mg/kg (n=6). During immediate allergic reactions, Rrs notably increases to 0.92 (0.10) cm H2O/mL/s in the control (p=0.0002), contrasted with lesser increases of 0.81 (0.12) cm H2O/mL/s at 1 mg/kg (p=0.01) and 1.06 (0.29) cm H2O/mL/s at 3 mg/kg (p=0.048) in the YM-264 treated groups. Furthermore, a significant re-elevation of Rrs to 0.72 (0.10) cm H2O/mL/s (p=0.0101) from baseline is observed in the control group 6 hours post-antigen challenge, whereas YM-264 at doses of 1 and 3 mg/kg markedly inhibits this rise in comparison. Additionally, YM-264 demonstrates a dose-dependent inhibition of eosinophil infiltration.

Chemical Properties

Molecular Weight	540.67
Formula	C₂₈H₃₆N₄O₅S
Cas No.	131888-54-5
Smiles	C(=C/C(O)=O)\C(O)=O.C(=O)(C1NC(SC1)C=2C=CC=NC2)N3CCN(CCC(C)(C)C4=CC=CC=C4)CC3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc